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DIS3L 抗体 (Alexa Fluor 594)

DIS3L 适用: 人, 小鼠, 大鼠 WB, IF (p) 宿主: 兔 Polyclonal Alexa Fluor 594
产品编号 ABIN2812395
发货至: 中国
  • 抗原 See all DIS3L 抗体
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    适用
    人, 小鼠, 大鼠
    宿主
    • 34
    • 3
    克隆类型
    • 37
    多克隆
    标记
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIS3L antibody is conjugated to Alexa Fluor 594
    应用范围
    • 32
    • 17
    • 14
    • 12
    • 5
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human DIS3L
    亚型
    IgG
    Top Product
    Discover our top product DIS3L Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    别名
    DIS3L (DIS3L 产品)
    别名
    DIS3L1 antibody, AV340375 antibody, RGD1308959 antibody, zgc:158615 antibody, DIS3 like exosome 3'-5' exoribonuclease antibody, DIS3-like exosome 3'-5' exoribonuclease antibody, DIS3L antibody, dis3l antibody, Dis3l antibody, dis3l.L antibody
    背景

    Synonyms: DIS3 like exonuclease 1, DIS3 mitotic control homolog S. cerevisiae like, FLJ38088, KIAA1955, MGC4562, DI3L1_HUMAN.

    Background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3? regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

    基因ID
    115752
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