SHC2 抗体 (AA 161-270) (Alexa Fluor 594)
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- 抗原 See all SHC2 抗体
- SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))
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抗原表位
- AA 161-270
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SHC2 antibody is conjugated to Alexa Fluor 594
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应用范围
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SHC2/Sck
- 亚型
- IgG
- Top Product
- Discover our top product SHC2 Primary Antibody
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anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2) (AA 718-829) antibody
SHC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A4 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2) (AA 129-163) antibodySHC2 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB58088 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2) (Internal Region) antibodySHC2 适用: 人, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2) (AA 718-829) antibodySHC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2) (AA 98-302) antibodySHC2 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))
- 别名
- SHC2/Sck (SHC2 产品)
- 别名
- SCK antibody, SHCB antibody, SLI antibody, 6720466E06 antibody, ShcB antibody, Sli antibody, SHC adaptor protein 2 antibody, SHC (Src homology 2 domain containing) transforming protein 2 antibody, SHC2 antibody, Shc2 antibody
- 背景
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Synonyms: Protein Sck, SCK, SH2 domain protein C2, SHC transforming protein 2, SHCB, Src homology 2 domain containing transforming protein C2, SHC2_HUMAN.
Background: Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, VEGF Signaling
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