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CYTIP 抗体 (AA 1-100) (Alexa Fluor 594)

CYTIP 适用: 人 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal Alexa Fluor 594
产品编号 ABIN2805652
发货至: 中国
  • 抗原 See all CYTIP 抗体
    CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
    抗原表位
    • 14
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 1-100
    适用
    • 23
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 23
    • 1
    克隆类型
    • 24
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CYTIP antibody is conjugated to Alexa Fluor 594
    应用范围
    • 23
    • 12
    • 12
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Horse,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP
    亚型
    IgG
    Top Product
    Discover our top product CYTIP Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
    别名
    PSCDBP/CYTIP (CYTIP 产品)
    别名
    B3-1 antibody, CASP antibody, CYBR antibody, CYTHIP antibody, HE antibody, PSCDBP antibody, A130053M09Rik antibody, AI462064 antibody, C80816 antibody, Cbp antibody, Cybr antibody, Pscdbp antibody, cytohesin 1 interacting protein antibody, CYTIP antibody, Cytip antibody, cytip antibody
    背景

    Synonyms: B31, CASP, Cbp HE, CYBR, CYTHIP, Cytip, CYTIP_HUMAN, Cytohesin binder and regulator, Cytohesin-associated scaffolding protein, Cytohesin-binding protein HE, Cytohesin-interacting protein, HE antibody Pleckstrin Homology Sec7 and Coiled-Coil Domains Binding Protein, Pleckstrin homology Sec7 and coiled-coil domains-binding protein.

    Background: CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.

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