ASAP2 抗体 (N-Term)
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- 抗原 See all ASAP2 抗体
- ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, 大鼠, 马, 犬, 兔, Pig, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ASAP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LSTDLHTIKQ AQDEERRQLI QLRDILKSAL QVEQKEDSQI RQSTAYSLHQ
- 预测反应
- Dog: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 78%, Rat: 93%, Zebrafish: 93%
- 产品特性
- This is a rabbit polyclonal antibody against ASAP2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human ASAP2
- Top Product
- Discover our top product ASAP2 Primary Antibody
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anti-ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) (AA 909-1006) antibody
ASAP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) (AA 700-750) antibodyASAP2 适用: 人, 小鼠, 大鼠, 猴, Opossum WB 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) (AA 1-120) antibodyASAP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) (Center) antibodyASAP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) (AA 500-760) antibodyASAP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 1006 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))
- 别名
- ASAP2 (ASAP2 产品)
- 别名
- DDEF2 antibody, ddef2 antibody, asap2 antibody, si:dkey-37o8.2 antibody, AMAP2 antibody, CENTB3 antibody, PAG3 antibody, PAP antibody, Pap-alpha antibody, SHAG1 antibody, 6530401G17Rik antibody, Ddef2 antibody, Gm1523 antibody, Gm592 antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b antibody, ASAP2 antibody, asap2.L antibody, asap1b antibody, asap2 antibody, Asap2 antibody
- 背景
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This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport.
Alias Symbols: AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
Protein Interaction Partner: SH3KBP1, MAP1LC3A, CTTN, Asap1, IKBKG, UBC, SUMO1, ELAVL1, ITSN1, THSD7A, GRB2, PACSIN3, PXN, BIN1, PTK2B, RAN, ARF6, REPS2, ARF5, ARF1, SRC, TBRG4,
Protein Size: 1006 - 分子量
- 112 kDa
- 基因ID
- 8853
- NCBI登录号
- NM_003887, NP_003878
- UniProt
- O43150
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