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KIR2DL3 抗体 (Middle Region)

KIR2DL3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2790295
发货至: 中国
  • 抗原 See all KIR2DL3 抗体
    KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
    抗原表位
    • 15
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    • 1
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    Middle Region
    适用
    • 47
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    宿主
    • 39
    • 8
    克隆类型
    • 40
    • 7
    多克隆
    标记
    • 21
    • 6
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    This KIR2DL3 antibody is un-conjugated
    应用范围
    • 20
    • 13
    • 13
    • 13
    • 10
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
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    Western Blotting (WB)
    序列
    GTSVVIILFI LLLFFLLHRW CCNKKNAVVM DQEPAGNRTV NREDSDEQDP
    预测反应
    Human: 100%
    产品特性
    This is a rabbit polyclonal antibody against KIR2DL3. It was validated on Western Blot.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of Human KIR2DL3
    Top Product
    Discover our top product KIR2DL3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeat freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
    别名
    KIR2DL3 (KIR2DL3 产品)
    别名
    CD158B2 antibody, CD158b antibody, GL183 antibody, KIR-023GB antibody, KIR-K7b antibody, KIR-K7c antibody, KIRCL23 antibody, NKAT antibody, NKAT2 antibody, NKAT2A antibody, NKAT2B antibody, p58 antibody, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 antibody, KIR2DL3 antibody
    背景
    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
    Protein Interaction Partner: APP, PTPN6, LCK, HLA-C,
    Protein Size: 243
    分子量
    26 kDa
    基因ID
    3804
    途径
    Cancer Immune Checkpoints
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