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- 抗原 See all CBFA2T2 抗体
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CBFA2T2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- AKESGISLKE IQVLARQWKV GPEKRVPAMP GSPVEVKIQS RSSPPTMPPL
- 预测反应
- Human: 100%
- 产品特性
- This is a rabbit polyclonal antibody against CBFA2T2. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human CBFA2T2
- Top Product
- Discover our top product CBFA2T2 Primary Antibody
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anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 201-304) antibody
CBFA2T2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 201-304) antibodyCBFA2T2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 1-575) antibodyCBFA2T2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 325-604) antibodyCBFA2T2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 325-604) antibodyCBFA2T2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (C-Term) antibodyCBFA2T2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) antibodyCBFA2T2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) antibodyCBFA2T2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) (AA 1-614) antibodyCBFA2T2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H3 unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 604 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- 别名
- CBFA2T2 (CBFA2T2 产品)
- 别名
- MTGR1 antibody, A430091M07 antibody, C330013D05Rik antibody, Cbfa2t2h antibody, EHT antibody, ZMYND3 antibody, p85 antibody, XETOR antibody, cbfa2t2-a antibody, CBFA2/RUNX1 translocation partner 2 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antibody, CBFA2/RUNX1 translocation partner 2 L homeolog antibody, Cbfa2t2 antibody, CBFA2T2 antibody, cbfa2t2.L antibody
- 背景
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In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. CBFA2T2 binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Alias Symbols: DKFZp313F2116, EHT, MTGR1, ZMYND3, p85
Protein Interaction Partner: PRDM14, PDP1, CBFA2T2, TCP1, MDFI, RUNX1T1, LBP, APP, ATXN1L, ATN1, RERE, RUNX1, SIN3A, NCOR1, HDAC3, FBXL19, TAL2, NEUROG1, ID3, GTF2E1, WDYHV1, CBFA2T3, NCOR2, CBFB, TAL1,
Protein Size: 604 - 分子量
- 67 kDa
- 基因ID
- 9139
- NCBI登录号
- NM_005093, NP_005084
- UniProt
- O43439
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