TLE2 抗体
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- 抗原 See all TLE2 抗体
- TLE2 (Transducin-Like Enhancer Protein 2 (TLE2))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TLE2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects endogenous levels of TLE2 protein. (region surrounding Lys214)
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- 纯度
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product TLE2 Primary Antibody
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anti-Transducin-Like Enhancer Protein 2 (TLE2) (C-Term) antibody
TLE2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transducin-Like Enhancer Protein 2 (TLE2) antibodyTLE2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Transducin-Like Enhancer Protein 2 (TLE2) (AA 201-250) antibodyTLE2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- DO NOT FREEZE!
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- TLE2 (Transducin-Like Enhancer Protein 2 (TLE2))
- 别名
- TLE2 (TLE2 产品)
- 别名
- TLE2 antibody, ESG antibody, ESG2 antibody, GRG2 antibody, Grg2 antibody, mKIAA4188 antibody, transducin like enhancer of split 2 antibody, transducin-like enhancer of split 2 antibody, TLE2 antibody, Tle2 antibody
- 背景
- The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor.Synonyms: GRG2, TLE2, Transducin-like enhancer protein 2
- 分子量
- approx. 65 kDa
- 基因ID
- 7089
- NCBI登录号
- NP_001138233
- UniProt
- Q04725
- 途径
- WNT signaling
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