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Sp3 抗体

Sp3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN272209
发货至: 中国
  • 抗原 See all Sp3 抗体
    Sp3 (Sp3 Transcription Factor (Sp3))
    适用
    • 48
    • 8
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 44
    • 4
    克隆类型
    • 44
    • 4
    多克隆
    标记
    • 21
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Sp3 antibody is un-conjugated
    应用范围
    • 42
    • 26
    • 13
    • 13
    • 7
    • 7
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    特异性
    This antibody detects endogenous levels of Sp3/4 protein. (region surrounding Gly659)
    交叉反应 (详细)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    纯度
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product Sp3 Primary Antibody
  • 应用备注
    ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1,0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    DO NOT FREEZE!
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    Sp3 (Sp3 Transcription Factor (Sp3))
    别名
    SP3 / SPR-2 (Sp3 产品)
    别名
    SPR2 antibody, D130027J01Rik antibody, SP3 antibody, sp3 antibody, zgc:162922 antibody, Sp3 transcription factor antibody, trans-acting transcription factor 3 antibody, sp3a transcription factor antibody, Sp3 transcription factor S homeolog antibody, SP3 antibody, Sp3 antibody, sp3a antibody, sp3.S antibody
    背景
    The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4(SPR-1). Sp transcription factors share similar structures but do not share similar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3,but not Sp2 or Sp4, interact with E2, a regulatory element for the β4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 mediated transcription. The gene encoding human Sp2 maps to chromosome 17p32.3.Synonyms: Transcription factor Sp3, Transcription factor Sp4
    分子量
    approx. 85 kDa
    基因ID
    6670
    NCBI登录号
    NP_001017371
    UniProt
    Q02447
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