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Urocortin 抗体

UCN 适用: 人, 大鼠, 小鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN271974
发货至: 中国
  • 抗原 See all Urocortin (UCN) 抗体
    Urocortin (UCN)
    适用
    人, 大鼠, 小鼠
    宿主
    • 18
    克隆类型
    • 18
    多克隆
    标记
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Urocortin antibody is un-conjugated
    应用范围
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody detects endogenous levels of Urocortin protein. (region surrounding Ala103)
    交叉反应 (详细)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    纯化方法
    Affinity Chromatography using epitope-specific immunogen.
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    Discover our top product UCN Primary Antibody
  • 应用备注
    ELISA: 1/5000approx. 1/10000. Immunohistochemisry on Paraffin Sections: 1/50approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid Freeze-Thaw cycles.
  • 抗原
    Urocortin (UCN)
    别名
    Urocortin / UCN (UCN 产品)
    别名
    UCN antibody, si:ch211-243j20.4 antibody, ucn antibody, wu:fq17a01 antibody, UI antibody, UROC antibody, Mpv17 antibody, Ucn1 antibody, urocortin antibody, urotensin 1 antibody, UCN antibody, uts1 antibody, Ucn antibody
    背景
    Urocortins 1, 2 and 3 are the mammalian homologs of fish urotensin I. Mammalian urocortin is a member of the corticotropin-releasing hormone(CRH) family that is expressed in a region of the rat midbrain. The distinct expression pattern in discrete brain regions suggests that it influences such behavior as feeding, anxiety and auditory processing. Synthetic human urocortin binds with high affinity to CRH receptors and acts in vitro to release ACTH from dispersed rat anterior pituitary cells. It is suggested that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite. The gene which encodes urocortin maps to human chromosome 2. Specifically, urocortin III is a specific ligand for CRF type 2 receptor which mediates stress-coping responses. Human urocortin I and III are expressed in the human heart. Urocortin III is also expressed in the pituitary gland, adrenal gland, GI tract, ovary, spleen, brain and kidney.
    基因ID
    7349
    NCBI登录号
    NP_003344
    UniProt
    P55089
    途径
    Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of Cell Size, Feeding Behaviour
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