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- 抗原 See all CD56 (NCAM1) 抗体
- CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD56 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 品牌
- BD Pharmingen™
- 产品特性
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The R19-760 monoclonal antibody specifically binds to NCAM-1 (Neural cell adhesion molecule 1) that is also known as CD56 and NKH1. NCAM-1 is a heavily glycosylated transmembrane protein and a member of the Ig supergene family. NCAM-1 represents an isoform of the neural cell adhesion molecule (NCAM). In the hematopoietic system, it is present on approximately 10 % to 25 % of peripheral blood lymphocytes. It is expressed on natural killer (NK) cells and a subset of T cells, NKT cells. It is not expressed on myeloid cells, erythrocytes or B cells. This molecule appears to function as an adhesion molecule and can serve as a panspecific NK-cell marker. The R19-760 antibody recognizes an epitope in the NCAM-1 (CD56) extracellular domain that resists destruction due to cellular fixation with BD Phosflow™ Lyse/Fix Buffer and permeabilization with BD Phosflow™ Perm Buffer III. Analyses of NCAM-1 (CD56) expression by Immunohistochemistry and
BD Pharmingen™ Purified Mouse Anti-Human NCAM-1 (CD56) - Purified - Clone R19-760 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human NCAM1 Recombinant Protein
- 克隆位点
- R19
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product NCAM1 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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Reciprocal activating interaction between natural killer cells and dendritic cells." in: The Journal of experimental medicine, Vol. 195, Issue 3, pp. 327-33, (2002) (PubMed).
: "SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells." in: Blood, Vol. 100, Issue 13, pp. 4581-9, (2002) (PubMed).
: "The biology of human natural killer-cell subsets." in: Trends in immunology, Vol. 22, Issue 11, pp. 633-40, (2001) (PubMed).
: "Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12." in: The Journal of experimental medicine, Vol. 184, Issue 5, pp. 1845-56, (1996) (PubMed).
: "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 12, pp. 4421-6, (1991) (PubMed).
: "Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction." in: The Journal of experimental medicine, Vol. 170, Issue 5, pp. 1757-61, (1989) (PubMed).
: "Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule." in: The Journal of experimental medicine, Vol. 169, Issue 6, pp. 2233-8, (1989) (PubMed).
: "Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 1, pp. 307-11, (1989) (PubMed).
: "Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing." in: Science (New York, N.Y.), Vol. 236, Issue 4803, pp. 799-806, (1987) (PubMed).
: "Cell adhesion molecules in the regulation of animal form and tissue pattern." in: Annual review of cell biology, Vol. 2, pp. 81-116, (1987) (PubMed).
: "Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis." in: The Journal of experimental medicine, Vol. 164, Issue 3, pp. 814-25, (1986) (PubMed).
: "The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 136, Issue 12, pp. 4480-6, (1986) (PubMed).
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Reciprocal activating interaction between natural killer cells and dendritic cells." in: The Journal of experimental medicine, Vol. 195, Issue 3, pp. 327-33, (2002) (PubMed).
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- 抗原
- CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
- 别名
- NCAM-1 CD56 (NCAM1 产品)
- 别名
- CD56 antibody, MSK39 antibody, NCAM antibody, fj56g09 antibody, ncam antibody, ncam1 antibody, wu:fj56g09 antibody, NCAM1 antibody, n-cam antibody, E-NCAM antibody, NCAM-1 antibody, Ncam antibody, Cd56 antibody, N-CAM antibody, N-CAM-1 antibody, NCAM-C antibody, NCAMC antibody, N-CAM-1-B antibody, NCAM-1-B antibody, ncam1-a antibody, ncam1-b antibody, neural cell adhesion molecule 1 antibody, neural cell adhesion molecule 1a antibody, neural cell adhesion molecule 1 S homeolog antibody, neural cell adhesion molecule 1 L homeolog antibody, NCAM1 antibody, ncam1a antibody, ncam1 antibody, LOC100085373 antibody, ncam1.S antibody, Ncam1 antibody, ncam1.L antibody
- 背景
- Synonyms: N-CAM-1, Neural cell adhesion molecule 1, NKH1, MSK39, Leu-19
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