(6 references)-
- 抗原 See all MICA/B (MICA/MICB) products
- MICA/B (MICA/MICB) (MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB))
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This MICA/B antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
-
Monoclonal antibody 6D4 reacts with MICA and MICB, distant homologs of major histocompatibility complex class I proteins. They are highly glycosylated molecules of approximately 70 kDa that are normally expressed in gut epithelium, are frequently associated with epithelial tumors and can be induced by some viral and bacterial infections. MIC are highly expressed on proliferating but not on quiescent epithelial cell lines, on which they can be heat-shock induced. MIC have similar functional and structural properties and are ligands for NKG2D, an activating receptor on most NK cells, CD8 T cells and ?d T cells. Expression of MIC has been observed on synoviocytes in rheumatoid arthritis and on epithelial cells in transplanted kidney and pancreas showing histological signs of rejection and or cellular injury. Profile of anti MIC A/B (clone 6D4) reactivity on HeLa cells analyzed by flow cytometry. Second step staining with Cat. No. 550589.
BD Pharmingen™ Purified Anti-Human MIC A/B - Purified - Clone 6D4 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Transfected cells
- 克隆位点
- 6D4
- 亚型
- IgG2a kappa
-
anti-MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB) antibody
MICA/MICB 适用: 人 FACS, IHC, IP 宿主: 小鼠 Monoclonal 6D4 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB) (AA 81-180) antibodyMICA/MICB 适用: 人 IF (cc), IF (p), IHC (fro), ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB) antibody (Biotin)MICA/MICB 适用: 人 FACS, IP, ICC 宿主: 小鼠 Monoclonal 6D4 Biotin
anti-MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB) antibody (FITC)MICA/MICB 适用: 人 FACS 宿主: 小鼠 Monoclonal 6D4 FITC
anti-MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB) antibody (APC)MICA/MICB 适用: 人 FACS 宿主: 小鼠 Monoclonal 6D4 APC
anti-MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB) antibody (PE)MICA/MICB 适用: 人 FACS 宿主: 小鼠 Monoclonal 6D4 PE
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
-
-
: "Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 16, pp. 9452-7, (2003) (PubMed).
: "MIC expression in renal and pancreatic allografts." in: Transplantation, Vol. 73, Issue 2, pp. 304-6, (2002) (PubMed).
: "MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function." in: Immunity, Vol. 15, Issue 1, pp. 83-93, (2001) (PubMed).
: "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells." in: Nature immunology, Vol. 2, Issue 3, pp. 255-60, (2001) (PubMed).
: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 727-9, (1999) (PubMed).
: "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 12, pp. 6879-84, (1999) (PubMed).
-
: "Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 16, pp. 9452-7, (2003) (PubMed).
-
- 抗原
- MICA/B (MICA/MICB) (MHC Class I Polypeptide-Related Sequence A/B (MICA/MICB))
- 别名
- MIC A/B (MICA/MICB 产品)
-
You are here:
