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HLAG 抗体

Name: HLAG 抗体
SKU: ABIN2689559
Availability: OutOfStock

HLAG 适用: 人 WB, FACS, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal 4H84 unconjugated

(6 references)

产品编号 ABIN2689559

发货至: 中国

Datasheet as PDF

抗原 See all HLAG 抗体

HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))
适用
121

7

4

1

1

1

1

1
人
宿主
65

62

3

1

1
小鼠
Compatible Secondaries
克隆类型
69

63
单克隆
标记
50

20

19

14

8

6

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This HLAG antibody is un-conjugated
应用范围
85

67

59

43

30

27

15

13

13

11

6

6

6

5

2

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

品牌

BD Pharmingen™

产品特性

HLA-G is a HLA class I molecule, but it is distinct from other class I molecules because of its quasi-monomorphism and restricted tissue distribution. It can be expressed as seven distinct protein forms. HLA-G1, -G2, G3, and -G4 are membrane bound while HLA-G5, -G6, and G7 are soluble. HLA-G is expressed in healthy individuals on amniocytes and cytotrophoblasts in the amnion-chorion. HLA-G interacts with inhibitory receptors such as ILT-2, ILT-4, p49 and KIR2DL4 expressed on NK cells, shifts the cytokine balance towards Th2 dominance, suppresses the proliferation of allogeneic CD4 lymphocytes and, in its soluble form, induces apoptosis of activated CD8 cells and inhibits cytolysis by NK cells. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of human HLA-G (denatured) reactivity on fixed, permeabilized JEG-3 cell line analyzed by flow cytometry. Fixed and permeabilized with Cat. No. 554714. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-human HLA-G Denatured - Purified - Clone 4H84 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

human HLA-G Denatured

克隆位点

4H84

亚型

IgG1 kappa

Top Product

Discover our top product HLAG Primary Antibody
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody
HLAG 适用: 人 WB, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal MEM-G-1 unconjugated

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (PE)
HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-G-9 PE

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody
HLAG 适用: 人 ELISA, FACS, IHC (fro), IP, ICC 宿主: 小鼠 Monoclonal MEM-G-9 unconjugated

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody
HLAG 适用: 人 ELISA, FACS, IHC (fro), IP, ICC 宿主: 小鼠 Monoclonal MEM-G-9 unconjugated

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (FITC)
HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal 87G FITC

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (FITC)
HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-G-9 FITC

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (Biotin)
HLAG 适用: 人 ELISA, FACS, IHC (fro), IP, ICC 宿主: 小鼠 Monoclonal MEM-G-9 Biotin

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (APC)
HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-G-9 APC

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (PE)
HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal 87G PE

anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) (AA 62-89) antibody
HLAG 适用: 人 WB, ELISA, FACS, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
Dorling, Monk, Lechler: "HLA-G inhibits the transendothelial migration of human NK cells." in: European journal of immunology, Vol. 30, Issue 2, pp. 586-93, (2000) (PubMed).

King, Allan, Bowen, Powis, Joseph, Verma, Hiby, McMichael, Loke, Braud: "HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells." in: European journal of immunology, Vol. 30, Issue 6, pp. 1623-31, (2000) (PubMed).

Le Bouteiller, Blaschitz: "The functionality of HLA-G is emerging." in: Immunological reviews, Vol. 167, pp. 233-44, (1999) (PubMed).

Le Bouteiller, Solier, Pröll, Aguerre-Girr, Fournel, Lenfant: "Placental HLA-G protein expression in vivo: where and what for?" in: Human reproduction update, Vol. 5, Issue 3, pp. 223-33, (1999) (PubMed).

Le Gal, Riteau, Sedlik, Khalil-Daher, Menier, Dausset, Guillet, Carosella, Rouas-Freiss: "HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes." in: International immunology, Vol. 11, Issue 8, pp. 1351-6, (1999) (PubMed).

McMaster, Zhou, Shorter, Kapasi, Geraghty, Lim, Fisher: "HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 5922-8, (1998) (PubMed).
抗原

HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

别名

HLA-G (HLAG 产品)

别名

MHC-G antibody, B-F antibody, B-F-S04 antibody, B-F-S05 antibody, B-F-S06 antibody, B-F-S07 antibody, B-FI antibody, B-FIV antibody, BF2 antibody, BFa2 antibody, BFw-03 antibody, BFw-05 antibody, BFz-01 antibody, major histocompatibility complex, class I, G antibody, MHC BF1 class I antibody, HLA-G antibody, BF1 antibody

途径

Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints