(1 reference)-
- 抗原 See all PDGFRA 抗体
- PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PDGFRA antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
- 品牌
- BD Pharmingen™
- 产品特性
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Reacts with platelet derived growth factor (PDGF) receptor α, CD140a, a 170 kD single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. They are structurally similar to M-CSF receptor and CD117 (c-kit). Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells. PDGF plays a role in wound healing and it also acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils. Functional PDGF is secreted as a dimer, disulfide linked, A and B chains (PDGFAA, PDGF-BB or PDGF-AB). Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ. The PDGF receptor α-subunit binds both PDGF A and B chains, whereas the receptor β-subunit binds only PDGF B chains. Both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis. αR1 is specific for αPDGFR and does not cross react with βPDGFR. It immunoprecipitates human, monkey, rabbit, pig, dog and cat αPDGFR. It does not recognize hamster, rat or mouse αPDGFR. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of MG-63 (osteosarcoma cell line) cells analyzed by flow cytometry
BD Pharmingen™ Purified Mouse Anti-Human CD140a - Purified - Clone αR1 (also known as Alpha-R1) - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 克隆位点
- AlphaR1
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product PDGFRA Primary Antibody
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anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 179-361) antibody
PDGFRA 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 5B11G5 unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 361-528) antibodyPDGFRA 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8E12F2 unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 331-719) antibodyPDGFRA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1-210) antibodyPDGFRA 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 179-361) antibodyPDGFRA 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 1A10A8 unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 698-727) antibodyPDGFRA 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB11101 unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1048-1077) antibodyPDGFRA 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1021-1089) antibodyPDGFRA 适用: 人, 小鼠, 大鼠, 犬 ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (C-Term) antibodyPDGFRA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1-1089) antibodyPDGFRA 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP." in: Oncogene, Vol. 9, Issue 2, pp. 517-25, (1994) (PubMed).
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: "The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP." in: Oncogene, Vol. 9, Issue 2, pp. 517-25, (1994) (PubMed).
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- 抗原
- PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
- 别名
- CD140a (PDGFRA 产品)
- 背景
- Synonyms: PDGF receptor α chain
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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