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- 抗原 See all IL1R2 抗体
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IL1R2 antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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CD121b, also known as interleukin-1 receptor type II (IL-1RII), has a significant role in the inflammatory response. Interleukin-1 receptor type II acts as a decoy receptor to regulate prolonged persistence of IL-1 by binding to IL-1 and preventing the formation of signaling complexes. Membrane IL-1 type II receptor forms a 60 kDa soluble IL-1 receptor type II upon proteolytic cleavage from various cell types after activation with secondary, IL-1 induced cytokines. The soluble IL-1 type II receptor consists of 398 amino acids and 29 amino acids within a short cytoplasmic domain. The MNC2 monoclonal antibody reacts with recombinant and native soluble human IL-1 receptor type II. Flow cytometric analysis for CD121b. Jurkat cells (Human T-cell leukemia, ATCC TIB-152) [Left Panel] or SR cells (Human lymphoblast, ATCC CRL-2262) [Right Panel] were stained either with a Mouse IgG1, κ isotype control (MN 555746) [dotted line] or with the Purified Mouse Anti-Human CD121b antibody (MN 552401) [solid line] in conjunction with a PE Goat Anti-Mouse Ig secondary antibody (MN 550589). Flow cytometry was performed on a BD FACSCalibur™ flow cytometry system.
BD Pharmingen™ Purified Mouse Anti-Human CD121B - Purified - Clone MNC2 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 克隆位点
- MNC2
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product IL1R2 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis." in: European journal of immunology, Vol. 30, Issue 3, pp. 867-75, (2000) (PubMed).
: "Role of metalloproteases in the release of the IL-1 type II decoy receptor." in: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31764-9, (1998) (PubMed).
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The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis." in: European journal of immunology, Vol. 30, Issue 3, pp. 867-75, (2000) (PubMed).
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- 抗原
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- 别名
- CD121B (IL1R2 产品)
- 别名
- CD121b antibody, CDw121b antibody, IL-1R-2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R2c antibody, IL1RB antibody, Il1r-2 antibody, IL-1R2 antibody, interleukin 1 receptor type 2 antibody, interleukin 1 receptor, type II antibody, interleukin-like antibody, IL1R2 antibody, Il1r2 antibody, KK34 antibody
- 背景
- Synonyms: IL-1 Receptor Type II, IL-1 RII
- 途径
- NF-kappaB Signaling
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