LAMP2 抗体
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- 抗原 See all LAMP2 抗体
- LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This LAMP2 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 品牌
- BD Pharmingen™
- 产品特性
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The M3/84 monoclonal antibody specifically binds to CD107b which is also known as Mac-3, Lysosome-associated membrane protein 2 (LAMP-2/Lamp2/Lamp II), and Lysosomal membrane glycoprotein type B (LGP-B). CD107b is a single-pass type I transmembrane glycoprotein that constitutes a major integral membrane protein of lysosomes and may play a role in lysosomal function. CD107b is also expressed on the surface of mouse mononuclear phagocytes. Surface expression of the 92-110- kDa glycoprotein antigen increases during differentiation of monocytes to activated macrophages and may play a role in adhesion. The M3/84 mAb can detect CD107b antigen on tissue macrophages, thioglycollate-elicited peritoneal macrophages, and some myeloid cell lines, but not on lymphocytes or monocytes. In the bone marrow, very few cells display CD107b antigen on the surface, but a large proportion express cytoplasmic CD107b. The M3/84 antibody has also been reported to stain dendritic cells and endothelium in sections of thymus (both medulla and cortex), lymph nodes, spleen (white pulp), and gut-associated lymphoid tissue.
BD Pharmingen™ Purified Rat Anti-Mouse CD107b - Purified - Clone M3/84 - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse C57Bl/6 peritoneal exudate cells
- 克隆位点
- M3-84
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product LAMP2 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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Identification of two lysosomal membrane glycoproteins." in: The Journal of cell biology, Vol. 101, Issue 1, pp. 85-95, (1985) (PubMed).
: "Characterization of subsets of bone marrow-derived macrophages by flow cytometry analysis." in: Journal of leukocyte biology, Vol. 37, Issue 2, pp. 121-36, (1985) (PubMed).
: "Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets." in: The American journal of pathology, Vol. 111, Issue 1, pp. 112-24, (1983) (PubMed).
: "Expression and induction in vitro of macrophage differentiation antigens on murine cell lines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 130, Issue 1, pp. 108-14, (1983) (PubMed).
: "Monoclonal antibody analysis of complex biological systems. Combination of cell hybridization and immunoadsorbents in a novel cascade procedure and its application to the macrophage cell surface." in: The Journal of biological chemistry, Vol. 256, Issue 8, pp. 3833-9, (1981) (PubMed).
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Identification of two lysosomal membrane glycoproteins." in: The Journal of cell biology, Vol. 101, Issue 1, pp. 85-95, (1985) (PubMed).
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- 抗原
- LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
- 别名
- CD107b (LAMP2 产品)
- 别名
- CD107b antibody, LAMP-2 antibody, LAMPB antibody, LGP110 antibody, Lamp-2 antibody, Lamp-2a antibody, Lamp-2b antibody, Lamp-2c antibody, Mac3 antibody, cd107b antibody, lamp-2 antibody, lampb antibody, LAMP2 antibody, lamp2 antibody, DKFZp459J126 antibody, LGP-B antibody, sb:cb587 antibody, wu:fb14a06 antibody, zgc:103532 antibody, lysosomal associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 S homeolog antibody, lysosomal membrane glycoprotein 2 antibody, LAMP2 antibody, Lamp2 antibody, lamp2.S antibody, lamp2 antibody
- 途径
- Autophagy
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