SHC1 抗体 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1) (pTyr349)

Details for Product anti-SHC1 Antibody No. ABIN2687774, 供应商: Log in to see
抗原
  • SHC1
  • SHC
  • SHCA
  • P66shc
  • si:dkey-246i14.4
  • wu:fc10h03
  • shc
  • p66shc
  • Shc
  • ShcA
  • p66
  • SHC adaptor protein 1
  • Shc1p
  • squalene--hopene cyclase
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC (Src homology 2 domain containing) transforming protein 1 L homeolog
  • src homology 2 domain-containing transforming protein C1
  • SHC1
  • shc1
  • Shc1
  • shc1.L
抗原表位
pTyr349
47
46
20
19
15
15
13
9
8
8
7
6
6
6
4
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
适用
人, 小鼠
262
198
153
6
6
2
1
1
1
1
1
1
宿主

239
35
克隆类型
多克隆
标记
This SHC1 antibody is un-conjugated
8
8
7
5
5
5
5
5
5
5
5
5
5
5
1
1
1
1
应用范围
Immunofluorescence (IF), Western Blotting (WB)
197
102
73
66
66
41
19
15
11
8
7
4
1
1
选项
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免疫原 The antibody was produced against synthesized phosphopeptide derived from human Shc1 around the phosphorylation site of tyrosine 349 (H-Q-YP-Y-N).
亚型 IgG
特异性 Shc1 (Phospho-Tyr349) antibody detects endogenous levels of Shc1 only when phosphorylated at tyrosine 349.
纯化方法 Affinity purified
Plasmids, Primers & others Plasmids, Primers & others SHC1 products on genomics-online (e.g. as negative or positive controls)
抗原 SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
别名 Shc1 (SHC1 Antibody 摘要)
背景 This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
途径 RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
应用备注 WB: 1:500~1:1000 IF:1:100~1:200
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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