RAF1 抗体 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1) (Ser338)

Details for Product anti-RAF1 Antibody No. ABIN2687749, 供应商: Log in to see
抗原
  • CRAF
  • NS5
  • Raf-1
  • c-Raf
  • c-raf
  • craf
  • raf1
  • RAF1
  • Afr-1
  • Afr1
  • Raf
  • mKIAA0854
  • 6430402F14Rik
  • AA990557
  • BB129353
  • Craf1
  • D830050J10Rik
  • v-Raf
  • raf
  • cRaf
  • Raf-1 proto-oncogene, serine/threonine kinase
  • Raf-1 proto-oncogene, serine/threonine kinase a
  • zinc fingers and homeoboxes 2
  • v-raf-leukemia viral oncogene 1
  • Raf-1 proto-oncogene, serine/threonine kinase S homeolog
  • RAF1
  • Raf1
  • raf1a
  • raf1
  • Zhx2
  • raf1.S
抗原表位
Ser338
84
76
48
48
47
39
34
34
34
31
31
22
20
20
19
19
16
15
15
15
14
14
10
10
9
8
8
7
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠
896
461
433
25
23
17
16
16
8
8
8
5
4
4
2
2
1
1
宿主

844
62
12
5
2
克隆类型
多克隆
标记
This RAF1 antibody is un-conjugated
46
46
45
30
30
29
14
14
12
12
12
12
12
12
12
12
12
2
2
2
2
2
2
2
2
2
1
1
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
568
419
269
182
156
111
62
50
31
18
16
10
2
2
2
1
选项
Supplier
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免疫原 The antibody was produced against synthesized non-phosphopeptide derived from human Raf1 around the phosphorylation site of serine 338 (R-D-SP-S-Y).
亚型 IgG
特异性 Raf1 (Ab-338) Antibody detects endogenous levels of total Raf1 protein.
纯化方法 Affinity purified
Plasmids, Primers & others Plasmids, Primers & others RAF1 products on genomics-online (e.g. as negative or positive controls)
抗原 V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
别名 Raf1 (RAF1 Antibody 摘要)
背景 This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
途径 MAPK Pathway, RTK signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
应用备注 WB: 1:500~1:1000 IHC: 1:50~1:100
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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