MYC (pThr58) 抗体

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抗原
  • RNCMYC
  • c-myc
  • mMyc
  • AU016757
  • Myc2
  • Niard
  • Nird
  • bHLHe39
  • MYC proto-oncogene, bHLH transcription factor
  • myelocytomatosis oncogene
  • Myc
抗原表位
pThr58
34
31
24
17
16
16
10
10
9
5
4
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠
303
104
98
7
3
3
3
3
3
2
1
1
1
1
1
1
1
宿主

220
77
4
2
2
1
克隆类型
单克隆
标记
非结合性
7
7
7
7
6
5
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
232
126
108
83
43
34
31
28
18
13
10
4
3
1
1
选项
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免疫原 The antiserum was produced against synthesized phosphopeptide derived from human Myc around the phosphorylation site of threonine 58 (L-P-TP-P-P).
特异性 Myc (phospho-Thr58) antibody detects endogenous levels of Myc only when phosphorylated at threonine 58.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
抗原
背景 This gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt',s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
应用备注 WB: 1:500~1:1000 IHC: 1:50~1:100
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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