LIMK2 抗体 (LIM Domain Kinase 2) (Thr505)

Details for Product anti-LIMK2 Antibody No. ABIN2687585, 供应商: Log in to see
抗原
  • xlimk2
  • zgc:91990
  • wu:fa97c09
  • wu:fk73e11
  • LIMK2
  • Limk2b
  • Link2
  • LIMK
  • 9430059K01
  • A930024P04Rik
  • C85310
  • Limk2a
  • LIM domain kinase 2 L homeolog
  • LIM domain kinase 2
  • LIM motif-containing protein kinase 2
  • limk2.L
  • limk2
  • LIMK2
  • Limk2
抗原表位
Thr505
32
14
10
10
8
6
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
适用
人, 小鼠
159
105
97
3
2
1
1
1
1
1
1
1
宿主

144
6
3
3
3
克隆类型
单克隆
标记
This LIMK2 antibody is un-conjugated
2
2
应用范围
Western Blotting (WB)
147
80
67
46
32
17
7
3
1
1
1
1
选项
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免疫原 The antiserum was produced against synthesized non-phosphopeptide derived from human LIMK2 around the phosphorylation site of threonine 505 (R-Y-TP-V-V).
特异性 LIMK2 (Ab-505) Antibody detects endogenous levels of total LIMK2 protein.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Plasmids, Primers & others Plasmids, Primers & others LIMK2 products on genomics-online (e.g. as negative or positive controls)
抗原 LIM Domain Kinase 2 (LIMK2)
别名 LIMK2 (LIMK2 Antibody 摘要)
背景 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. This gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
应用备注 WB: 1:500~1:1000
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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