LIMK2 抗体 (LIM Domain Kinase 2) (Thr505)

Details for Product anti-LIMK2 Antibody No. ABIN2687585, 供应商: Log in to see
抗原
  • xlimk2
  • zgc:91990
  • wu:fa97c09
  • wu:fk73e11
  • LIMK2
  • Limk2b
  • Link2
  • LIMK
  • 9430059K01
  • A930024P04Rik
  • C85310
  • Limk2a
  • LIM domain kinase 2 L homeolog
  • LIM domain kinase 2
  • LIM motif-containing protein kinase 2
  • limk2.L
  • limk2
  • LIMK2
  • Limk2
抗原表位
Thr505
31
14
10
10
8
6
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
适用
人, 小鼠
157
103
95
3
2
1
1
1
1
1
1
1
宿主

141
6
4
3
3
克隆类型
单克隆
标记
This LIMK2 antibody is un-conjugated
2
2
应用范围
Western Blotting (WB)
145
76
68
43
28
15
8
3
1
1
1
选项
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免疫原 The antiserum was produced against synthesized non-phosphopeptide derived from human LIMK2 around the phosphorylation site of threonine 505 (R-Y-TP-V-V).
特异性 LIMK2 (Ab-505) Antibody detects endogenous levels of total LIMK2 protein.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Plasmids, Primers & others Plasmids, Primers & others LIMK2 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 LIMK2 (LIMK2 Antibody 摘要)
背景 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. This gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
应用备注 WB: 1:500~1:1000
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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