LIM Domain Kinase 1 抗体 (LIMK1) (pThr508)

Details for Product anti-LIMK1 Antibody No. ABIN2687584, 供应商: Log in to see
抗原
  • limk1
  • xlimk1
  • GB16654
  • LIMK1
  • LIMK
  • LIMK-1
  • LIM domain kinase 1
  • LIM domain kinase 1a
  • LIM domain kinase 1 L homeolog
  • LIM-domain containing, protein kinase
  • LIMK1
  • limk1a
  • limk1
  • CpipJ_CPIJ000717
  • LOC413152
  • Limk1
  • limk1.L
抗原表位
pThr508
55
15
13
10
10
9
8
7
5
5
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
适用
人, 小鼠
241
113
103
7
5
2
2
2
2
2
1
1
宿主

168
76
3
克隆类型
单克隆
标记
This LIM Domain Kinase 1 antibody is un-conjugated
8
8
6
4
4
4
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
205
103
90
69
41
36
19
18
15
13
5
4
1
选项
Supplier
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免疫原 The antiserum was produced against synthesized phosphopeptide derived from human LIMK1 around the phosphorylation site of threonine 508 (R-Y-TP-V-V).
特异性 LIMK1 (phospho-Thr508) antibody detects endogenous levels of LIMK1 only when phosphorylated at threonine 508.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Plasmids, Primers & others Plasmids, Primers & others LIM Domain Kinase 1 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 LIMK1 (LIMK1 Antibody 摘要)
背景 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
途径 Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
应用备注 WB: 1:500~1000 IHC: 1:50~1:100
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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