LIM Domain Kinase 1 抗体 (LIMK1) (Thr508)

Details for Product anti-LIMK1 Antibody No. ABIN2687583, 供应商: Log in to see
抗原
  • limk1
  • xlimk1
  • GB16654
  • LIMK1
  • LIMK
  • LIMK-1
  • LIM domain kinase 1
  • LIM domain kinase 1a
  • LIM domain kinase 1 L homeolog
  • LIM-domain containing, protein kinase
  • LIMK1
  • limk1a
  • limk1
  • CpipJ_CPIJ000717
  • LOC413152
  • Limk1
  • limk1.L
抗原表位
Thr508
56
15
13
10
9
9
8
7
5
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
适用
人, 小鼠
243
115
105
8
5
2
2
2
2
2
1
1
宿主

170
76
3
克隆类型
单克隆
标记
This LIM Domain Kinase 1 antibody is un-conjugated
8
8
6
4
4
4
1
1
1
1
1
1
1
1
1
1
1
应用范围
Western Blotting (WB)
207
103
95
70
43
36
20
18
15
13
5
4
1
1
选项
Supplier
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免疫原 The antiserum was produced against synthesized non-phosphopeptide derived from human LIMK1 around the phosphorylation site of threonine 508 (R-Y-TP-V-V).
特异性 LIMK1 (Ab-508) antibody detects endogenous levels of total LIMK1 protein.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Plasmids, Primers & others Plasmids, Primers & others LIM Domain Kinase 1 products on genomics-online (e.g. as negative or positive controls)
抗原 LIM Domain Kinase 1 (LIMK1)
别名 LIMK1 (LIMK1 Antibody 摘要)
背景 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
途径 Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
应用备注 WB: 1:500~1:1000
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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