LCK 抗体 (Lymphocyte-Specific Protein tyrosine Kinase) (pTyr393)

Details for Product anti-LCK Antibody No. ABIN2687581, 供应商: Log in to see
抗原
  • zgc:136695
  • LCK
  • Hck-3
  • Lsk
  • Lskt
  • p56
  • p56Lck
  • LSK
  • YT16
  • p56lck
  • pp58lck
  • P56LCK
  • tkl
  • Lck1
  • Lcktkr
  • LCK proto-oncogene, Src family tyrosine kinase
  • lymphocyte protein tyrosine kinase
  • lck
  • LCK
  • Lck
抗原表位
pTyr393
74
32
30
27
17
15
14
12
12
11
9
7
7
6
6
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠
465
235
159
13
13
9
8
5
5
5
3
3
1
宿主

296
155
17
克隆类型
单克隆
标记
This LCK antibody is un-conjugated
13
12
12
11
9
9
8
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
应用范围
Western Blotting (WB)
397
167
81
81
76
58
52
35
26
12
6
4
4
4
3
3
2
1
1
选项
Supplier
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Supplier Product No.
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免疫原 The antiserum was produced against synthesized phosphopeptide derived from human Lck around the phosphorylation site of tyrosine 393 (N-E-YP-T-A).
特异性 Lck (phospho-Tyr393) antibody detects endogenous levels of Lck only when phosphorylated at tyrosine 393.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Plasmids, Primers & others Plasmids, Primers & others LCK products on genomics-online (e.g. as negative or positive controls)
抗原
别名 Lck (LCK Antibody 摘要)
背景 This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
途径 TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
应用备注 WB: 1:500~1:1000
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
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