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Klra4 抗体

Klra4 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 4E5 unconjugated
产品编号 ABIN2665245
发货至: 中国
  • 抗原 See all Klra4 products
    Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
    适用
    小鼠
    宿主
    大鼠
    克隆类型
    单克隆
    应用范围
    Flow Cytometry (FACS)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    4E5
    亚型
    IgG2a kappa
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
    别名
    Ly49D (Klra4 产品)
    别名
    Chok antibody, Klra32 antibody, Ly-49d antibody, Ly49d antibody, ly49r<129> antibody, killer cell lectin-like receptor, subfamily A, member 4 antibody, Klra4 antibody
    背景
    Ly49D is a type II transmembrane protein belonging to the Ly49 family of NK-cell receptors in the C-type lectin superfamily. Ly49D is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He and SJL mouse strains, but not Balb/c, DBA/2, AKR and CBA/J. The receptors form homodimers that bind to MHC class I alloantigens. Unlike inhibitory Ly49 family members, Ly49D lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) but contains a cytoplasmic immunoreceptor tyrosine-based activation motif. The activating receptor Ly49D delivers stimulatory signals for target cell lysis upon interacting with H2-Dd, Dr and Dsp2, but not with H2b or H2k class I antigens. Cross-linking of Ly49D activates intracellular kinase activity and calcium mobilization in NK cells. In 129/J mice, 4E5 antibody cross-reacts with Ly49O, LY49R and Ly49V.
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