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NOTUM 抗体

NOTUM 适用: 人, 小鼠 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN265168
发货至: 中国
  • 抗原 See all NOTUM 抗体
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    适用
    • 38
    • 3
    • 2
    人, 小鼠
    宿主
    • 38
    克隆类型
    • 38
    多克隆
    标记
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOTUM antibody is un-conjugated
    应用范围
    • 34
    • 21
    • 13
    • 13
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    This antibody detects Notum.
    纯化方法
    Purified
    免疫原
    Recombinant full-length notum protein from Mouse
    亚型
    IgG
    Top Product
    Discover our top product NOTUM Primary Antibody
  • 应用备注
    Western blot: 5-10 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline with 0.08 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the product (in aliquots) at -20 °C. Can be shipped at 2-8 °C.
  • 抗原
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    别名
    Notum (NOTUM 产品)
    别名
    5730593N15Rik antibody, RGD1307119 antibody, notum, palmitoleoyl-protein carboxylesterase antibody, notum pectinacetylesterase homolog (Drosophila) antibody, NOTUM, palmitoleoyl-protein carboxylesterase antibody, NOTUM antibody, Notum antibody
    背景
    Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the alpha/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
    基因ID
    77583
    NCBI登录号
    NP_780472
    UniProt
    Q8R116
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