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IL-15 抗体

IL15 适用: 人 WB, IP, EIA, IHC (fro) 宿主: 小鼠 Monoclonal BDI150 unconjugated
产品编号 ABIN263855
发货至: 中国
  • 抗原 See all IL-15 (IL15) 抗体
    IL-15 (IL15) (Interleukin 15 (IL15))
    适用
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    宿主
    • 69
    • 20
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    小鼠
    克隆类型
    • 78
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    单克隆
    标记
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    This IL-15 antibody is un-conjugated
    应用范围
    • 71
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    Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    This antibody reacts to IL-15.
    产品特性
    Synonyms: IL-15
    纯化方法
    Ion exchange chromatography
    免疫原
    Recombinant Human IL-15
    克隆位点
    BDI150
    亚型
    IgG1
    Top Product
    Discover our top product IL15 Primary Antibody
  • 应用备注
    ELISA: 1: 20,000. Western blot. Immunoprecipitation.
    限制
    仅限研究用
  • 溶解方式
    Restore with sterile water. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
    浓度
    1,0 mg/mL (prior to lyophilization)
    缓冲液
    PBS
    储存条件
    4 °C/-20 °C
    储存方法
    Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one monthor (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    IL-15 (IL15) (Interleukin 15 (IL15))
    别名
    Interleukin-15 / IL15 (IL15 产品)
    别名
    IL15 antibody, AI503618 antibody, IL-15 antibody, interleukin 15 antibody, IL15 antibody, Il15 antibody
    背景
    IL15 (114 amino acids) is a cytokine that regulates T and natural killer cell activation and proliferation. It has a predicted molecular mass of approximately 12.5 kDa. Human IL15 shares approximately 97 % and 73 % amino acid sequence identity with simian and mouse IL15, respectively. Both human and simian IL15 are active on mouse cells. IL15 was initially isolated from the simian kidney epithelial cell line CV1/EBNA. It has also been isolated from mouse and human cell sources. The cytokines IL15 and IL2 share many biological properties and stimulatory activities (T, B, and NK cells). Both IL15 and IL2 stimulate mouse CTLL2 cells. In activated peripheral blood T lymphocytes, IL2 is highly expressed but the expression of IL15 is not detectable. There is no sequence homology between IL15 and IL2, though computer modeling indicates both possess a four alpha helical bundle structure. IL15 competes for binding sites with IL2, as both IL2 and IL15 stimulate the growth of cells through the IL2 receptor. IL15 mRNA is expressed in many cell types and tissues including adherent peripheral blood mononuclear cells, fibroblasts, and epithelial cells, monocytes, placenta, and skeletal muscle. IL-15 (14-15 kD) is a member of the four alpha-helical bundle family of cytokines. It is very similar to IL-2, except that IL-15 has an IL-15 alpha receptor subunit. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. This implies that IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.Synonyms: IL-15
    基因ID
    3600
    UniProt
    P40933
    途径
    JAK/STAT Signaling, Glycosaminoglycan Metabolic Process
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