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EGLN3 抗体

EGLN3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2463514
发货至: 中国
  • 抗原 See all EGLN3 抗体
    EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
    适用
    • 43
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    人, 小鼠, 大鼠
    宿主
    • 44
    • 4
    • 1
    克隆类型
    • 45
    • 4
    多克隆
    标记
    • 30
    • 4
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    This EGLN3 antibody is un-conjugated
    应用范围
    • 35
    • 23
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    Western Blotting (WB), ELISA
    纯化方法
    Antibody is purified by peptide affinity chromatography method.
    免疫原
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EGLN3.
    Top Product
    Discover our top product EGLN3 Primary Antibody
  • 应用备注
    EGLN3 antibody can be used for detection of EGLN3 by ELISA at 1:1562500. EGLN3 antibody can be used for detection of EGLN3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
    浓度
    1 mg/mL
    缓冲液
    Antibody is lyophilized in PBS buffer with 2 % sucrose.
    注意事项
    As with any antibody avoid repeat freeze-thaw cycles.
    储存条件
    4 °C/-20 °C
    储存方法
    For short periods of storage (days) store at 4 °C. For longer periods of storage, store EGLN3 antibody at -20 °C.
  • 抗原
    EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
    别名
    EGLN3 (EGLN3 产品)
    别名
    zgc:77019 antibody, wu:fj78a08 antibody, EGLN3 antibody, phd3 antibody, PHD-3 antibody, PHD3 antibody, SM-20 antibody, 2610021G09Rik antibody, AI505553 antibody, AI648162 antibody, Hif-p4h-3 antibody, Phd3 antibody, HIFP4H3 antibody, HIFPH3 antibody, egl-9 family hypoxia-inducible factor 3 antibody, egl-9 family hypoxia inducible factor 3 antibody, egl-9 family hypoxia-inducible factor 3 L homeolog antibody, egln3 antibody, EGLN3 antibody, egln3.L antibody, Egln3 antibody
    背景
    EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
    分子量
    27 kDa
    基因ID
    112399
    NCBI登录号
    NP_071356
    UniProt
    Q9H6Z9
    途径
    Positive Regulation of Endopeptidase Activity
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