(1 reference)-
- 抗原 See all CBLL1 抗体
- CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CBLL1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 过滤
- 0.2 μm filtered
- Top Product
- Discover our top product CBLL1 Primary Antibody
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anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1) (AA 1-100) antibody
CBLL1 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1) (C-Term) antibodyCBLL1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 斑马鱼, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1) (AA 413-462) antibodyCBLL1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1) (N-Term) antibodyCBLL1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1) (C-Term) antibodyCBLL1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For Western blotting, immunofluorescence and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex." in: Nature cell biology, Vol. 4, Issue 3, pp. 222-31, (2002) (PubMed).
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: "Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex." in: Nature cell biology, Vol. 4, Issue 3, pp. 222-31, (2002) (PubMed).
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- 抗原
- CBLL1 (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))
- 别名
- Hakai (CBLL1 产品)
- 别名
- HAKAI antibody, RNF188 antibody, zgc:55308 antibody, CBLL1 antibody, AI467391 antibody, Hakai antibody, c-Cbl-like antibody, cbll1 antibody, hakai antibody, rnf188 antibody, Cbl proto-oncogene like 1 antibody, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog antibody, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase antibody, Casitas B-lineage lymphoma-like 1 antibody, Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog antibody, CBLL1 antibody, cbll1.S antibody, Cbll1 antibody, cbll1 antibody, cbll1.L antibody
- 背景
- The polyclonal antibody reacts with human Hakai, a c-Cbl-like protein. Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.
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