S100A8 抗体 (S100 Calcium Binding Protein A8)

Details for Product anti-S100A8 Antibody No. ABIN2192036, 供应商: Log in to see
抗原
  • 60B8AG
  • CAGA
  • CFAG
  • CGLA
  • CP-10
  • L1Ag
  • MA387
  • MIF
  • MRP8
  • NIF
  • P8
  • Mrp8
  • S100A8
  • 60B8Ag
  • AI323541
  • B8Ag
  • CFAg
  • Caga
  • p8
  • MRP-8
  • S100 calcium binding protein A8
  • S100 calcium binding protein A8 (calgranulin A)
  • S100A8
  • S100a8
适用

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克隆类型 (克隆位点)
单克隆 ()
标记
This S100A8 antibody is un-conjugated
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应用范围
Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
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选项
Supplier
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Supplier Product No.
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克隆位点 7C12-4
过滤 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others S100A8 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 s100a8 (S100A8 Antibody 摘要)
背景 The monoclonal antibody 7C12/4 recognizes an epitope on the S100A8 (MRP-8) protein. The calcium- binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60 % of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti- S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
途径 Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity
应用备注 For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
限制 仅限研究用
缓冲液 PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
有效期 12 months
有引用在: Robinson, Tessier, Poulsom, Hogg: "The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3658-65, 2002 (PubMed).

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