(2 references)-
- 抗原 See all Desmoglein 2 (DSG2) 抗体
- Desmoglein 2 (DSG2)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Desmoglein 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应 （详细）
- Cross reactivity: Human desmoglein-1 : No, Human desmoglein-3 : No
- 过滤
- 0.2 μm filtered
- 克隆位点
- 6D8
- 亚型
- IgG1
- Top Product
- Discover our top product DSG2 Primary Antibody
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anti-Desmoglein 2 (DSG2) antibody
DSG2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 72-121) antibodyDSG2 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人, 大鼠, 小鼠, Cow, 犬, Pig, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 275-533) antibodyDSG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 183-331) antibodyDSG2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 37-164) antibodyDSG2 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 10D2 unconjugated
anti-Desmoglein 2 (DSG2) (AA 51-150) antibodyDSG2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) antibodyDSG2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) antibodyDSG2 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 6D8 unconjugated
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- 应用备注
- For immune fluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Positive A431 Cells control
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
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: "No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases." in: Journal of dermatological science, Vol. 32, Issue 2, pp. 137-41, (2003) (PubMed).
: "Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains." in: Journal of cell science, Vol. 109 ( Pt 5), pp. 1143-54, (1996) (PubMed).
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: "No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases." in: Journal of dermatological science, Vol. 32, Issue 2, pp. 137-41, (2003) (PubMed).
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- 抗原
- Desmoglein 2 (DSG2)
- 别名
- Desmoglein-2 (DSG2 产品)
- 背景
- The monoclonal antibody 6D8 recognizes the extracellular domain of human desmoglein-2. Desmogleins and desmocollins are members of the cadherin family of transmembrane proteins that together make up the core of the desmosome, a structure that provides transmembrane strength to tissues undergoing mechanical stress. The desmosomal cadherins, desmogleins and desmocollins, mediate calcium-dependent cell-cell adhesion by forming homotypic and heterotypic interactions with one another. The multiprotein desmosomal complex also includes the cytoplasmic desmosomal plaque proteins plakoglobin, phakophilins, and desmoplakin, which bind to the intracellular domain of the desmogleins and function to anchor the keratin intermediate filament network to site of cell-cell contacts. In human, four desmogleins have been identified (Dsg1-4). Desmogleins are synthesized with a signal peptide that directs them to the endoplasmic reticulum and a proregion that is removed during protein processing. The mature protein includes four highly conserved extracellular domains (EC 1-4) and a fifth membrane proximal, more variable EC domain that is referred to as the "extracellular anchor domain. Desmoglein-2 is expressed on various cells including simple epithelia and myocardium, tumors and and many cell cultures. Desmogleins play critical roles in cell adhesion and skin blistering diseases, as they are the target antigens of autoimmune antibodies and bacterial toxins. Desmosomal dysfunction has been implicated in a number of diseases, including striate palmoplantar keratoderma, skin fragility, and ectodermal dysplasia, and most recently arrhythmic right ventricular cardiomyopathy (ARVC). Aliases Dsg2, Cadherin family member 5, HDGC Immunogen Extracellular EC4 domain
- 途径
- Cell-Cell Junction Organization
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