CXCL10 抗体 (Chemokine (C-X-C Motif) Ligand 10) (FITC)

Details for Product anti-CXCL10 Antibody No. ABIN2191896
抗原
适用

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宿主
小鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
This CXCL10 antibody is conjugated to FITC
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应用范围
Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Western Blotting (WB)
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选项
克隆位点 6D4
过滤 0.2 μm filtered
抗原
别名 C-X-C Motif Chemokine 10 (CXCL10 Antibody 摘要)
背景 The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the α-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFNγ inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, psoriasis and acute anterior uveitis. Various observations strongly suggest a role for the C-X-C chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. Furthermore IP-10 is associated with acute rejection processes estimated by the predictive properties of urinary IP-10 expression for the short- and long-term graft function after kidney transplantation. Aliases 10 kDa interferon gamma-induced protein, CXCL10, Small-inducible cytokine B10 Immunogen Recombinant human IP-10
应用备注 For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Acitvated plasmacytoid dendritic cells control Negative Normal liver control 1
限制 仅限研究用
缓冲液 PBS, containing 1.0 % bovine serum albumin and 0.02 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
有引用在: Curbishley, Eksteen, Gladue, Lalor, Adams: "CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow." in: The American journal of pathology, Vol. 167, Issue 3, pp. 887-99, 2005 (PubMed).

Giustizieri, Albanesi, Scarponi, De Pità, Girolomoni: "Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo." in: The American journal of pathology, Vol. 161, Issue 4, pp. 1409-18, 2002 (PubMed).

Hamamdzic, Phillips-Dorsett, Altman-Hamamdzic, London, London: "Reovirus triggers cell type-specific proinflammatory responses dependent on the autocrine action of IFN-beta." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 280, Issue 1, pp. L18-29, 2001 (PubMed).