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GEMC1 抗体 (Center)

GMNC 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1887716
发货至: 中国
  • 抗原 See all GEMC1 (GMNC) 抗体
    GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))
    抗原表位
    • 1
    • 1
    Center
    适用
    人, 小鼠
    宿主
    • 2
    克隆类型
    • 2
    多克隆
    标记
    • 2
    This GEMC1 antibody is un-conjugated
    应用范围
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    19 amino acid peptide near the center of human GEMC1.
    Top Product
    Discover our top product GMNC Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    注意事项
    Avoid freezing and thawing repeatly.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • 抗原
    GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))
    别名
    GEMC1 (GMNC 产品)
    别名
    GEMC1 antibody, Gemc1 antibody, Gm1778 antibody, Gm606 antibody, gemc1 antibody, xGEMC1 antibody, geminin coiled-coil domain containing antibody, geminin coiled-coil domain containing S homeolog antibody, GMNC antibody, Gmnc antibody, gmnc.S antibody
    背景
    The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication.GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function.GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation.GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication.Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
    Synonyms: Geminin coiled-coil domain-containing protein 1
    NCBI登录号
    NP_001140158
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