MAP1
适用: 大鼠
IP
宿主: 小鼠
Monoclonal
MP-1
Magnetic Particles
限制
仅限研究用
状态
Liquid
缓冲液
PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事项
Avoid freezing and thawing repeatly.
储存条件
4 °C/-20 °C
储存方法
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.Disruption of this process has been implicated in a variety of diseases such as cancer.Members of the Bcl-2 family are known to be critical regulators of this process.These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains.A related protein termed MAP-1 has recently been identified.This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed.It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo.It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.