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SHP1 抗体 (AA 247-277)

PTPN6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17225 unconjugated
产品编号 ABIN1882123
发货至: 中国
  • 抗原 See all SHP1 (PTPN6) 抗体
    SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
    抗原表位
    • 35
    • 12
    • 7
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 247-277
    适用
    • 120
    • 73
    • 55
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 108
    • 14
    • 1
    克隆类型
    • 95
    • 28
    多克隆
    标记
    • 61
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This SHP1 antibody is un-conjugated
    应用范围
    • 86
    • 34
    • 27
    • 22
    • 20
    • 14
    • 14
    • 12
    • 9
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This PTPN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-277 amino acids from the Central region of human PTPN6.
    克隆位点
    RB17225
    亚型
    Ig Fraction
    Top Product
    Discover our top product PTPN6 Primary Antibody
  • 应用备注
    IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Korporaal, Koekman, Verhoef, van der Wal, Bezemer, Van Eck, Akkerman: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, (2009) (PubMed).

    Cho, Oh, Zhu: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, (2008) (PubMed).

  • 抗原
    SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
    别名
    PTPN6 (PTPN6 产品)
    别名
    HCPH antibody, HPTP1C antibody, PTP-1C antibody, SH-PTP1 antibody, SHP-1 antibody, SHP-1L antibody, SHP1 antibody, DRPLA antibody, Hcph antibody, Ptp1C antibody, me antibody, motheaten antibody, Ptph6 antibody, Shp-1 antibody, fj22f05 antibody, wu:fj22f05 antibody, zgc:55501 antibody, ptpn6 antibody, protein tyrosine phosphatase, non-receptor type 6 antibody, protein tyrosine phosphatase, non-receptor type 6 L homeolog antibody, PTPN6 antibody, Ptpn6 antibody, ptpn6 antibody, ptpn6.L antibody
    背景
    PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
    分子量
    67561
    NCBI登录号
    NP_002822, NP_536858, NP_536859
    UniProt
    P29350
    途径
    JAK/STAT Signaling, TCR Signaling, TLR signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
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