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FAK 抗体 (N-Term)

Name: FAK 抗体 (N-Term)
SKU: ABIN1882052
Availability: OutOfStock

PTK2 适用: 人 WB 宿主: 小鼠 Monoclonal 1297CT261-163-145 unconjugated

Western blot analysis of lysate from HUVEC cell line,using PTK2 Antibody (N-term) (ABIN1882052 and ABIN2843641).

1 image

(3 references)

产品编号 ABIN1882052

发货至: 中国

Datasheet as PDF

抗原 See all FAK (PTK2) 抗体

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
抗原表位
37

29

27

25

23

23

18

18

16

16

13

11

8

7

6

6

5

5

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 1-128, N-Term
适用
324

285

220

22

21

18

17

12

9

7

6

5

3

3

3

2

1

1

1

1
人
宿主
337

17

3

2

1

1
小鼠
Compatible Secondaries
克隆类型
328

33
单克隆
标记
177

19

16

13

13

13

13

13

13

13

10

9

9

9

9

9

2

1
This FAK antibody is un-conjugated
应用范围
297

126

122

121

108

75

68

51

31

30

25

5

2

2
Western Blotting (WB)

纯化方法

This antibody is purified through a protein G column, followed by dialysis against PBS.

免疫原

This PTK2 antibody is generated from a mice immunized with a recombinant protein between 1-128 amino acids from the N-terminal region of human PTK2.

克隆位点

1297CT261-163-145

亚型

IgG1

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PTK2 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 10H7E9 unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Nusbaum, Mikkelsen, Zody, Asakawa, Taudien, Garber, Kodira, Schueler, Shimizu, Whittaker, Chang, Cuomo, Dewar, FitzGerald, Yang, Allen, Anderson, Asakawa, Blechschmidt, Bloom, Borowsky, Butler, Cook et al.: "DNA sequence and analysis of human chromosome 8. ..." in: Nature, Vol. 439, Issue 7074, pp. 331-5, (2006) (PubMed).

Whitney, Chan, Blake, Cosand, Neubauer, Aruffo, Kanner: "Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK." in: DNA and cell biology, Vol. 12, Issue 9, pp. 823-30, (1993) (PubMed).

André, Becker-André: "Expression of an N-terminally truncated form of human focal adhesion kinase in brain." in: Biochemical and biophysical research communications, Vol. 190, Issue 1, pp. 140-7, (1993) (PubMed).
抗原

FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

别名

PTK2 (PTK2 产品)

别名

FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody

背景

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation, required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1, most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1, GIT2 and SHC1, this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

分子量

119233

UniProt

Q05397

途径

Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling