TYSY (AA 265-294), (C-Term) 抗体

ABIN1881964 产品详细信息, 供应商: Log in to see
抗原
抗原表位
C-Term, AA 265-294
3
1
适用

5
宿主

5
克隆类型 (克隆位点)
多克隆 ()
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
5
5
4
3
2
1
选项
Supplier
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免疫原 This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.
克隆位点 RB20041
纯化方法 This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
背景 Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Synonyms: TYMS, TS, Thymidylate synthase
NCBI登录号 NP_001062
UniProt P04818
应用备注 WB: 1:2000,IHC: 1:500,IF: 1:50,FACS: 1:50
限制 仅限研究用
状态 Liquid
浓度 0.5 mg/mL
缓冲液 Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
储存液 Sodium azide
注意事项 WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
厂商提供的图像
Western Blotting (WB) image for anti-TYSY (AA 265-294), (C-Term) antibody (ABIN1881964) TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c...
Immunohistochemistry (IHC) image for anti-TYSY (AA 265-294), (C-Term) antibody (ABIN1881964) TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c...
Immunohistochemistry (IHC) image for anti-TYSY (AA 265-294), (C-Term) antibody (ABIN1881964) TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c...
Immunofluorescence (IF) image for anti-TYSY (AA 265-294), (C-Term) antibody (ABIN1881964) TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c...
Immunofluorescence (IF) image for anti-TYSY (AA 265-294), (C-Term) antibody (ABIN1881964) TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c...
Flow Cytometry (FACS) image for anti-TYSY (AA 265-294), (C-Term) antibody (ABIN1881964) TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c...
有引用在: Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, 2009 (PubMed).

Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, 1996 (PubMed).

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