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SQSTM1 抗体 (C-Term)

SQSTM1 适用: 人 WB 宿主: 兔 Polyclonal RB41445 unconjugated
产品编号 ABIN1881829
发货至: 中国
  • 抗原 See all SQSTM1 抗体
    SQSTM1 (Sequestosome 1 (SQSTM1))
    抗原表位
    • 18
    • 17
    • 15
    • 12
    • 11
    • 11
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 383-409, C-Term
    适用
    • 171
    • 64
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 145
    • 24
    • 1
    • 1
    克隆类型
    • 144
    • 27
    多克隆
    标记
    • 77
    • 13
    • 12
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SQSTM1 antibody is un-conjugated
    应用范围
    • 121
    • 58
    • 50
    • 40
    • 25
    • 23
    • 18
    • 16
    • 14
    • 13
    • 10
    • 5
    • 3
    • 2
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    • 1
    • 1
    Western Blotting (WB)
    预测反应
    M, Rat
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This SQSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-409 amino acids from the C-terminal region of human SQSTM1.
    克隆位点
    RB41445
    亚型
    Ig Fraction
    Top Product
    Discover our top product SQSTM1 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Visconti, Langston, Alonso, Goodman, Selby, Fraser, Ralston: "Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 25, Issue 11, pp. 2368-73, (2010) (PubMed).

    Ding, Ni, Li, Liao, Chen, Stolz, Dorn, Yin: "Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27879-90, (2010) (PubMed).

    Jain, Lamark, Sjøttem, Larsen, Awuh, Øvervatn, McMahon, Hayes, Johansen: "p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22576-91, (2010) (PubMed).

    Lau, Wang, Zhao, Villeneuve, Wu, Jiang, Sun, White, Zhang: "A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62." in: Molecular and cellular biology, Vol. 30, Issue 13, pp. 3275-85, (2010) (PubMed).

    Gao, Cao, Bao, Zuo, Xie, Cai, Fu, Zhang, Wu, Zhang, Chen: "Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation." in: Nature cell biology, Vol. 12, Issue 8, pp. 781-90, (2010) (PubMed).

  • 抗原
    SQSTM1 (Sequestosome 1 (SQSTM1))
    别名
    SQSTM1 (SQSTM1 产品)
    别名
    SQSTM1 antibody, sqstm1 antibody, MGC79491 antibody, A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, OSF-6 antibody, Osi antibody, STAP antibody, ZIP antibody, sb:cb621 antibody, zgc:85784 antibody, sequestosome 1 antibody, sequestosome 1 L homeolog antibody, SQSTM1 antibody, sqstm1 antibody, Sqstm1 antibody, sqstm1.L antibody
    背景
    This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
    分子量
    47687
    NCBI登录号
    NP_001135770, NP_001135771, NP_003891
    UniProt
    Q13501
    途径
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
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