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BRAF 抗体

BRAF 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22681 unconjugated
产品编号 ABIN1881118
发货至: 中国
  • 抗原 See all BRAF 抗体
    BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))
    适用
    • 201
    • 72
    • 51
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    宿主
    • 183
    • 18
    • 2
    克隆类型
    • 167
    • 36
    多克隆
    标记
    • 122
    • 13
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    • 8
    • 8
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    This BRAF antibody is un-conjugated
    应用范围
    • 114
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    • 70
    • 32
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    • 18
    • 13
    • 13
    • 8
    • 8
    • 8
    • 5
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    Western Blotting (WB), Flow Cytometry (FACS)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This BRAF antibody is generated from rabbits immunized with BRAF recombinant protein.
    克隆位点
    RB22681
    亚型
    Ig Fraction
    Top Product
    Discover our top product BRAF Primary Antibody
  • 应用备注
    WB: 1:1000. FC: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Weisbart, Chan, Heinze, Mory, Nishimura, Colburn: "BRAF drives synovial fibroblast transformation in rheumatoid arthritis." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34299-303, (2010) (PubMed).

    Hingorani, Jacobetz, Robertson, Herlyn, Tuveson: "Suppression of BRAF(V599E) in human melanoma abrogates transformation." in: Cancer research, Vol. 63, Issue 17, pp. 5198-202, (2003) (PubMed).

    Lee, Yoo, Soung, Kim, Park, Kim, Lee, Park, Cho, Kim, Ko, Kim, Nam, Lee, Lee: "BRAF mutations in non-Hodgkin's lymphoma." in: British journal of cancer, Vol. 89, Issue 10, pp. 1958-60, (2003) (PubMed).

    Davies, Bignell, Cox, Stephens, Edkins, Clegg, Teague, Woffendin, Garnett, Bottomley, Davis, Dicks, Ewing, Floyd, Gray, Hall, Hawes, Hughes, Kosmidou, Menzies, Mould, Parker, Stevens, Watt, Hooper et al.: "Mutations of the BRAF gene in human cancer. ..." in: Nature, Vol. 417, Issue 6892, pp. 949-54, (2002) (PubMed).

    Naoki, Chen, Richards, Sugarbaker, Meyerson: "Missense mutations of the BRAF gene in human lung adenocarcinoma." in: Cancer research, Vol. 62, Issue 23, pp. 7001-3, (2002) (PubMed).

    Stephens, Sithanandam, Copeland, Kaplan, Rapp, Morrison: "95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site." in: Molecular and cellular biology, Vol. 12, Issue 9, pp. 3733-42, (1992) (PubMed).

  • 抗原
    BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))
    别名
    BRAF (BRAF 产品)
    别名
    B-RAF1 antibody, BRAF1 antibody, NS7 antibody, RAFB1 antibody, C-RMIL antibody, RMIL antibody, B-Raf antibody, braf1 antibody, rafb1 antibody, b-raf1 antibody, sierrabraf antibody, BRAF antibody, 9930012E13Rik antibody, AA120551 antibody, AA387315 antibody, AA473386 antibody, B-raf antibody, Braf-2 antibody, Braf2 antibody, C230098H17 antibody, C87398 antibody, D6Ertd631e antibody, braf antibody, fc48g01 antibody, wu:fc48g01 antibody, B-Raf proto-oncogene, serine/threonine kinase antibody, B-Raf proto-oncogene, serine/threonine kinase S homeolog antibody, Braf transforming gene antibody, si:dkey-222f8.3 antibody, BRAF antibody, Braf antibody, braf.S antibody, braf antibody, si:dkey-222f8.3 antibody
    背景
    BRAF, a member of the RAF subfamily of Ser/Thr protein kinases, is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neurons. This cytoplasmic protein is expressed in brain and testis. Defects in BRAF are involved in a wide range of cancers including lung cancer and non-Hodgkin lymphoma (NHL). This protein contains 1 zinc-dependent phorbol-ester and DAG binding domain.
    分子量
    84437
    NCBI登录号
    NP_004324
    UniProt
    P15056
    途径
    MAPK Pathway, RTK signaling, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy
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