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ABCB1 抗体 (AA 632-693)

ABCB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6G11F8 unconjugated
产品编号 ABIN1724927
发货至: 中国
  • 抗原 See all ABCB1 抗体
    ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
    抗原表位
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 632-693
    适用
    • 68
    • 16
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 47
    • 25
    小鼠
    克隆类型
    • 44
    • 28
    单克隆
    标记
    • 49
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ABCB1 antibody is un-conjugated
    应用范围
    • 38
    • 24
    • 23
    • 19
    • 15
    • 13
    • 10
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human ABCB1 (AA: 632-693) expressed in E. coli.
    克隆位点
    6G11F8
    亚型
    IgG1
    Top Product
    Discover our top product ABCB1 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Rubi?, Ho?ysz, Barczak, Gryczka, ?aci?ski, Jagielski, Czernikiewicz, Pó?rolniczak, Wojewoda, Perz, Bia?ek, Morze, Kandu?a, Lisiak, Mrozikiewicz, Grodecka-Gazdecka, Rybczy?ska: "Study of ABCB1 polymorphism frequency in breast cancer patients from Poland." in: Pharmacological reports : PR, Vol. 64, Issue 6, pp. 1560-6, (2013) (PubMed).

    Zhang, Wang, Cai, Jiang, Zhou, Yang, Chen, Chen, Dou: "Downregulation of gene MDR1 by shRNA to reverse multidrug-resistance of ovarian cancer A2780 cells." in: Journal of cancer research and therapeutics, Vol. 8, Issue 2, pp. 226-31, (2012) (PubMed).

  • 抗原
    ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
    别名
    ABCB1 (ABCB1 产品)
    别名
    ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1a antibody, p-gp antibody, xemdr antibody, Mdr1 antibody, Mdr1b antibody, Pgy-1 antibody, Pgy1 antibody, mdr antibody, ABCB1 antibody, PGP1 antibody, ATP binding cassette subfamily B member 1 antibody, ATP binding cassette subfamily B member 1A antibody, ATP binding cassette subfamily B member 1 L homeolog antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antibody, ABCB1 antibody, Abcb1a antibody, abcb1.L antibody, Abcb1b antibody, Abcb1 antibody
    背景

    Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. ,

    Aliases: CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170

    分子量
    141.5 kDa
    基因ID
    5243
    HGNC
    5243
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