电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

CD45 抗体 (AA 928-989)

PTPRC 适用: 人 IHC, WB, ELISA 宿主: 小鼠 Monoclonal 5D3A3 unconjugated
产品编号 ABIN1724924
发货至: 中国
  • 抗原 See all CD45 (PTPRC) 抗体
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    抗原表位
    • 18
    • 16
    • 16
    • 14
    • 13
    • 11
    • 11
    • 9
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 928-989
    适用
    • 393
    • 227
    • 79
    • 29
    • 20
    • 16
    • 15
    • 10
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 281
    • 178
    • 148
    • 2
    • 1
    • 1
    小鼠
    克隆类型
    • 466
    • 137
    • 1
    单克隆
    标记
    • 174
    • 60
    • 51
    • 48
    • 39
    • 15
    • 13
    • 11
    • 10
    • 10
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD45 antibody is un-conjugated
    应用范围
    • 503
    • 206
    • 151
    • 127
    • 126
    • 74
    • 67
    • 58
    • 47
    • 27
    • 17
    • 15
    • 14
    • 13
    • 12
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. coli.
    克隆位点
    5D3A3
    亚型
    IgG1
    Top Product
    Discover our top product PTPRC Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Pujari, Eligar, Kumar, Nagre, Inamdar, Swamy, Shastry: "CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC." in: Biochemical and biophysical research communications, Vol. 419, Issue 4, pp. 708-14, (2012) (PubMed).

    Gopal, Pagel, Fromm, Wilbur, Press: "131I anti-CD45 radioimmunotherapy effectively targets and treats T-cell non-Hodgkin lymphoma." in: Blood, Vol. 113, Issue 23, pp. 5905-10, (2009) (PubMed).

  • 抗原
    CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
    别名
    PTPRC (PTPRC 产品)
    别名
    PTPRC antibody, si:dkeyp-47c5.1 antibody, B220 antibody, CD45 antibody, CD45R antibody, GP180 antibody, L-CA antibody, LCA antibody, LY5 antibody, T200 antibody, Cd45 antibody, Ly-5 antibody, Lyt-4 antibody, loc antibody, Lca antibody, RT7 antibody, cd45 antibody, protein tyrosine phosphatase, receptor type C antibody, protein tyrosine phosphatase, receptor type, C antibody, receptor-type tyrosine-protein phosphatase C antibody, PTPRC antibody, ptprc antibody, LOC100074271 antibody, Ptprc antibody
    背景

    Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. , , ,

    Aliases: LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180

    分子量
    147.3 kDa
    基因ID
    5788
    HGNC
    5788
    途径
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
You are here:
客服