LAMTOR2 抗体 (AA 3-100) (HRP)
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- 抗原 See all LAMTOR2 抗体
- LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
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抗原表位
- AA 3-100
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LAMTOR2 antibody is conjugated to HRP
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应用范围
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human ROBLD3
- 亚型
- IgG
- Top Product
- Discover our top product LAMTOR2 Primary Antibody
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anti-Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2) (AA 41-70) antibody
LAMTOR2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33457 unconjugated
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- 应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
- 别名
- ROBLD3 (LAMTOR2 产品)
- 别名
- ENDAP antibody, HSPC003 antibody, MAPBPIP antibody, MAPKSP1AP antibody, ROBLD3 antibody, Ragulator2 antibody, p14 antibody, 2010111E04Rik antibody, AL022628 antibody, Mapbpip antibody, P14 antibody, Rab25 antibody, Robld3 antibody, RGD1562501 antibody, cg5189 antibody, endap antibody, hspc003 antibody, mapbpip antibody, mapbpip-B antibody, mapksp1ap antibody, ragulator2 antibody, robld3 antibody, robld3-b antibody, zgc:100811 antibody, lamtor2 antibody, lamtor2-a antibody, lamtor2-b antibody, mapbpip-A antibody, robld3-a antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog antibody, LAMTOR2 antibody, Lamtor2 antibody, lamtor2.S antibody, lamtor2 antibody, lamtor2.L antibody
- 背景
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Synonyms: ENDAP, Endosomal adaptor protein p14, HSPC003, LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Late endosomal/lysosomal Mp1 interacting protein, Late endosomal/lysosomal Mp1-interacting protein, LTOR2_HUMAN, MAPBPIP, MAPKSP1 adaptor protein, MAPKSP1AP, Mitogen activated protein binding protein interacting protein, Mitogen-activated protein-binding protein-interacting protein, p14, Ragulator complex protein LAMTOR2, Ragulator2, Roadblock domain containing 3, Roadblock domain containing protein 3, Roadblock domain-containing protein 3, ROBLD 3, RP11 336K24.9.
Background: MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. MAPBPIP (mitogen-activated protein-binding protein-interacting protein), also known as p14 and late endosomal/lysosomal MP1-interacting protein, functions as an adaptor protein augmenting the regulation of the MAP kinase cascade. Partner proteins MAPBPIP and MP1 are structurally almost identical each with a five-stranded -sheet flanked between a two-helix and one-helix layer. MAPBPIP compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. Knockdown of the individual proteins in the MP1/MAPBPIP complex resulted in decreased expression of the partner proteins which implies greater stability of the heterodimeric complex than either MP1 or MAPBPIP individually. Early research suggests the MP1-MAPBPIP-MEK-1 signaling complex may be critical in the regulation of tissue homeostasis.
- 途径
- PI3K-Akt Signaling
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