FANCC 抗体 (AA 61-160) (Cy5)
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- 抗原 See all FANCC 抗体
- FANCC (Fanconi Anemia, Complementation Group C (FANCC))
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抗原表位
- AA 61-160
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FANCC antibody is conjugated to Cy5
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人
- 预测反应
- Mouse,Rat,Dog,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human FANCC
- 亚型
- IgG
- Top Product
- Discover our top product FANCC Primary Antibody
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anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 319-558) antibody
FANCC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-558) antibodyFANCC 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (Center) antibodyFANCC 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-210) antibodyFANCC 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-100) antibodyFANCC 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6E7 unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (C-Term) antibodyFANCC 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 527-555), (C-Term) antibodyFANCC 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB24076 unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 529-558), (C-Term) antibodyFANCC 适用: 人 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-558) antibodyFANCC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (N-Term) antibodyFANCC 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- FANCC (Fanconi Anemia, Complementation Group C (FANCC))
- 别名
- FANCC (FANCC 产品)
- 别名
- zgc:154105 antibody, FANCC antibody, fa3 antibody, fac antibody, facc antibody, FA3 antibody, FAC antibody, FACC antibody, BB116513 antibody, Facc antibody, Fanconi anemia complementation group C antibody, Fanconi anemia, complementation group C antibody, Fanconi anemia complementation group C L homeolog antibody, FANCC antibody, fancc antibody, fancc.L antibody, Fancc antibody
- 背景
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Synonyms: bA80I15.1, FA 3, FA3, FAC, FACC, FANCC, FANCC_HUMAN, Fanconi anemia complementation group C, Fanconi anemia complementation group C protein, Fanconi anemia group C protein, Fanconi pancytopenia type 3, FLJ14675, Protein FACC.
Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
- 基因ID
- 2176
- 途径
- DNA Damage Repair
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