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GARNL1 抗体 (AA 631-730) (Alexa Fluor 488)

RALGAPA1 适用: 大鼠 IF (cc), IF (p) 宿主: 兔 Polyclonal Alexa Fluor 488
产品编号 ABIN1695229
发货至: 中国
  • 抗原 See all GARNL1 (RALGAPA1) 抗体
    GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
    抗原表位
    • 14
    • 1
    • 1
    • 1
    AA 631-730
    适用
    • 23
    • 14
    • 10
    大鼠
    宿主
    • 26
    • 2
    克隆类型
    • 26
    • 2
    多克隆
    标记
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GARNL1 antibody is conjugated to Alexa Fluor 488
    应用范围
    • 12
    • 12
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    大鼠
    预测反应
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human GARNL1
    亚型
    IgG
    Top Product
    Discover our top product RALGAPA1 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
    别名
    GARNL1 (RALGAPA1 产品)
    别名
    GARNL1 antibody, GRIPE antibody, TULIP1 antibody, Garnl1 antibody, Tulip1 antibody, tulip1 antibody, tulip1.2 antibody, 2310003F20Rik antibody, 4930400K19Rik antibody, AI563624 antibody, mKIAA0884 antibody, p240 antibody, Ral GTPase activating protein catalytic alpha subunit 1 antibody, Ral GTPase activating protein, alpha subunit 1 (catalytic) antibody, Ral GTPase activating protein, alpha subunit 1 antibody, RALGAPA1 antibody, Ralgapa1 antibody, ralgapa1 antibody
    背景

    Synonyms: DKFZp566D133, DKFZp667F074, GAP related interacting partner to E12, GARN L1, GARNL 1, GRIPE, GTPase activating Rap/RanGAP domain like 1, KIAA0884, Tuberin like protein 1, TULIP 1. TULIP1, RGPA1_HUMAN.

    Background: GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.

    基因ID
    253959
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