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SETD2 抗体 (AA 803-1103)

SETD2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1682666
发货至: 中国
  • 抗原 See all SETD2 抗体
    SETD2 (SET Domain Containing 2 (SETD2))
    抗原表位
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 803-1103
    适用
    • 27
    • 7
    • 5
    • 2
    • 2
    • 2
    宿主
    • 23
    • 3
    • 1
    克隆类型
    • 24
    • 3
    多克隆
    标记
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SETD2 antibody is un-conjugated
    应用范围
    • 12
    • 11
    • 10
    • 10
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    序列
    SLCNSEAENI EPSVMKISSN SFMNVHLESK PVICDSRNLT DHSKFACEEY KQSIGSTSSA SVNHFDDLYQ PIGSSGIASS LQSLPPGIKV DSLTLLKCGE NTSPVLDAVL KSKKSSEFLK HAGKETIVEV GSDLPDSGKG FASRENRRNN GLSGKCLQEA QEEGNSILPE RRGRPEISLD ERGEGGHVHT SDDSEVVFSS CDLNLTMEDS DGVTYALKCD SSGHAPEIVS TVHEDYSGSS ESSNDESDSE DTDSDDSSIP RNRLQSVVVV PKNSTLPMEE TSPCSSRSSQ SYRHYSDHWE D
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • Huang, Gu, Li: "H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation." in: The Journal of biological chemistry, Vol. 293, Issue 20, pp. 7811-7823, (2019) (PubMed).

    Jia, Long, Miron, Yin, Wei, Zhang, Wu: "Setd2 is associated with strontium-induced bone regeneration." in: Acta biomaterialia, Vol. 53, pp. 495-505, (2018) (PubMed).

    Chen, Liu, Liu, Xia, Zhang, Han, Jiang, Wang, Cao: "Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity." in: Cell, Vol. 170, Issue 3, pp. 492-506.e14, (2017) (PubMed).

    Zhu, Lei, Ju, Wang, Huang, Yang, Shao, Zhu, Wei, Fu, Li, Wu: "SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing." in: Nucleic acids research, Vol. 45, Issue 1, pp. 92-105, (2017) (PubMed).

  • 抗原
    SETD2 (SET Domain Containing 2 (SETD2))
    别名
    SETD2 (SETD2 产品)
    别名
    Kif9 antibody, HBP231 antibody, HIF-1 antibody, HIP-1 antibody, HYPB antibody, KMT3A antibody, SET2 antibody, p231HBP antibody, SET domain containing 2 antibody, Setd2 antibody, SETD2 antibody
    背景
    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.,SETD2,HBP231,HIF-1,HIP-1,HSPC069,HYPB,KMT3A,LLS,SET2,p231HBP,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,SETD2
    分子量
    175 kDa/192 kDa/287 kDa
    基因ID
    29072
    UniProt
    Q9BYW2
    途径
    Tube Formation
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