Tumor Necrosis Factor 抗体 (TNF) (Middle Region)

Details for Product anti-TNF Antibody No. ABIN1582141, 供应商: Log in to see
抗原
  • DIF
  • TNF-alpha
  • TNFA
  • TNFSF2
  • RATTNF
  • Tnfa
  • tnf
  • TNF-a
  • TNFalpha
  • Tnfsf1a
  • TNFa
  • cTNF
  • Tnf-alpha
  • tnfa-like
  • TNF-ALPHA
  • dif
  • tnfa
  • xtnf
  • tnfsf2
  • tnf-alpha
  • Cachectin
  • tumor necrosis factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • lipopolysaccharide induced TNF factor
  • tumor necrosis factor a (TNF superfamily, member 2)
  • TNF
  • Tnf
  • tnf
  • tnfb
  • tnf-alpha
  • LITAF
  • LOC103694380
  • tnfa
抗原表位
Middle Region
51
44
27
27
24
22
19
17
15
10
10
10
8
8
7
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
适用
小鸡, 牛, 犬, 马, 人, 小鼠, 猪, 大鼠
1274
461
356
143
136
119
118
58
52
41
29
16
14
12
9
7
6
4
4
4
2
2
1
1
1
1
宿主

946
529
178
48
10
9
8
7
5
3
2
克隆类型
多克隆
标记
This Tumor Necrosis Factor antibody is un-conjugated
171
97
73
51
49
33
31
28
28
26
26
26
26
25
25
25
24
13
9
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
应用范围
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
876
855
622
327
316
229
224
185
137
105
97
67
29
28
26
25
20
18
14
11
9
9
7
6
6
6
5
5
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TNF-alpha.
交叉反应 牛, 小鸡, 犬, 马, 猪, 大鼠
纯化方法 Antibody was purified by Protein-A affinity chromatography.
别名 TNF-alpha (TNF Antibody 摘要)
背景

Alternate Names: Tumor necrosis factor, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, TNF, TNFA, TNFSF2

Description: Tumor necrosis factor alpha (TNF-alpha) is a cytokine that binds to the TNF-R1 and TNF-R2 receptors. TNF-alpha is mainly secreted by macrophages and induces cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion, and therefore found in cachexia accompanying diverse cancers and infections. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and to HBV infection.

UniProt P01375
途径 NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
应用备注 E: 1:500-1:1,000, WB: 1:100-1:500, IHC: 1:100-1:500
限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 Each vial contains 0.1 mg IgG in 0.1 mL (1 mg/mL) of PBS pH 7.4 with 0.09 % sodium azide.
储存液 Sodium azide
注意事项 Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
注意事项 Minimize freeze-thaw cycles.
储存条件 -20 °C
储存方法 Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
有效期 12 months
厂商提供的图像
 image for anti-Tumor Necrosis Factor (TNF) (Middle Region) antibody (ABIN1582141) TNF-alpha staining in human skin. Paraffin-embedded human skin is stained with TNF-al...
有引用在: Gennaro, Claudino, Cestari, Ceolin, Germino, Garlet, de Assis: "Green Tea Modulates Cytokine Expression in the Periodontium and Attenuates Alveolar Bone Resorption in Type 1 Diabetic Rats." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134784, 2016 (PubMed).

Huber, Meabon, Hoffer, Zhang, Hoekstra, Pagulayan, McMillan, Mayer, Banks, Kraemer, Raskind, McGavern, Peskind, Cook: "Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction." in: Neuroscience, Vol. 319, pp. 206-20, 2016 (PubMed).

Pajer, Nemes, Berzsenyi, Kovács, Pirity, Pajenda, Nógrádi, Dinnyés: "Grafted murine induced pluripotent stem cells prevent death of injured rat motoneurons otherwise destined to die." in: Experimental neurology, Vol. 269, pp. 188-201, 2015 (PubMed).

Bhol, Tracey, Lemos, Lyng, Erlich, Keane, Quesenberry, Holdorf, Schlehuber, Clark, Fox: "AVX-470: a novel oral anti-TNF antibody with therapeutic potential in inflammatory bowel disease." in: Inflammatory bowel diseases, Vol. 19, Issue 11, pp. 2273-81, 2014 (PubMed).

Hwang, Hsu, Yu, Liu, Yang: "Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice." in: PLoS ONE, Vol. 8, Issue 4, pp. e60730, 2013 (PubMed).

Sun, Li, He, Zhang, Tao: "Neuroprotective effect of minocycline in a rat model of branch retinal vein occlusion." in: Experimental eye research, Vol. 113, pp. 105-16, 2013 (PubMed).

Yasuda, Kato, Yamanaka, Iimori, Utsumi, Kitahara, Iwata, Matsuno, Amagase, Yabe-Nishimura, Takeuchi: "Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 10, pp. G1133-42, 2012 (PubMed).

Byrne, Rath, Hladik, Niederreiter, Bonelli, Frantal, Smolen, Scheinecker: "A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model." in: PLoS ONE, Vol. 7, Issue 4, pp. e35194, 2012 (PubMed).

Choi, Lim, Hwang, Lee, Cho, Kim: "Anti-ischemic and anti-inflammatory activity of (S)-cis-verbenol." in: Free radical research, Vol. 44, Issue 5, pp. 541-51, 2010 (PubMed).

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