Tumor Necrosis Factor 抗体 (TNF) (C-Term)

Details for Product anti-TNF Antibody No. ABIN1582064, 供应商: Log in to see
抗原
  • DIF
  • TNF-alpha
  • TNFA
  • TNFSF2
  • RATTNF
  • Tnfa
  • tnf
  • TNF-a
  • TNFalpha
  • Tnfsf1a
  • TNFa
  • cTNF
  • Tnf-alpha
  • tnfa-like
  • TNF-ALPHA
  • dif
  • tnfa
  • xtnf
  • tnfsf2
  • tnf-alpha
  • Cachectin
  • tumor necrosis factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • lipopolysaccharide induced TNF factor
  • tumor necrosis factor a (TNF superfamily, member 2)
  • TNF
  • Tnf
  • tnf
  • tnfb
  • tnf-alpha
  • LITAF
  • LOC103694380
  • tnfa
抗原表位
C-Term
51
44
27
27
23
22
19
17
15
10
10
10
8
8
7
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
适用
犬, 马, 人, 小鼠, 猪, 大鼠, 绵羊
1273
459
356
143
136
119
118
58
53
40
28
16
14
11
9
7
6
4
4
4
3
2
1
1
1
1
宿主

945
528
178
48
10
9
8
7
5
3
2
克隆类型
多克隆
标记
This Tumor Necrosis Factor antibody is un-conjugated
171
97
73
51
49
33
31
28
28
26
26
26
26
25
25
25
24
13
9
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
应用范围
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
876
853
620
325
314
227
224
185
137
105
97
67
29
28
26
25
20
18
14
11
9
9
7
6
6
6
5
5
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TNF-alpha.
交叉反应 猫, 犬, 马, 小鼠, 猪, 大鼠, 绵羊
纯化方法 Antibody was purified by immunogen-affinity chromatography.
别名 TNF-alpha (TNF Antibody 摘要)
背景

Alternate Names: Tumor necrosis factor, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, TNF, TNFA, TNFSF2

Description: Tumor necrosis factor alpha (TNF-alpha) is a cytokine that binds to the TNF-R1 and TNF-R2 receptors. TNF-alpha is mainly secreted by macrophages and induces cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion, and therefore found in cachexia accompanying diverse cancers and infections. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and to HBV infection.

UniProt P01375
途径 NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
应用备注 E: 1:1,000-1:5,000, WB: 1:100-1:500, IHC: 1:100-1:500
限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 Each vial contains 0.1 mg IgG in 0.1 mL (1 mg/mL) of PBS pH 7.4, 1 mg/mL BSA with 0.09 % sodium azide.
储存液 Sodium azide
注意事项 Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
注意事项 Minimize freeze-thaw cycles.
储存条件 -20 °C
储存方法 Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
有效期 12 months
厂商提供的图像
 image for anti-Tumor Necrosis Factor (TNF) (C-Term) antibody (ABIN1582064) TNF-alpha staining in human mammary cancer. Paraffin-embedded human mammary cancer is...
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor (TNF) (C-Term) antibody (ABIN1582064) anti-Tumor Necrosis Factor (TNF) (C-Term) antibody (Image 2)
Western Blotting (WB) image for anti-Tumor Necrosis Factor (TNF) (C-Term) antibody (ABIN1582064) anti-Tumor Necrosis Factor (TNF) (C-Term) antibody (Image 3)
有引用在: Mulas, Espa, Fenu, Spiga, Cossu, Pillai, Carboni, Simbula, Jadžić, Angius, Spolitu, Batetta, Lecca, Giuffrida, Carta: "Differential induction of dyskinesia and neuroinflammation by pulsatile versus continuous l-DOPA delivery in the 6-OHDA model of Parkinson's disease." in: Experimental neurology, Vol. 286, pp. 83-92, 2017 (PubMed).

Póvoa, Oliveira, Basílio-de-Oliveira, Nuovo, Chagas, Salomão, Mota, Paes: "Peripheral Organs of Dengue Fatal Cases Present Strong Pro-Inflammatory Response with Participation of IFN-Gamma-, TNF-Alpha- and RANTES-Producing Cells." in: PLoS ONE, Vol. 11, Issue 12, pp. e0168973, 2017 (PubMed).

Pisanu, Lecca, Mulas, Wardas, Simbula, Spiga, Carta: "Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease." in: Neurobiology of disease, Vol. 71, pp. 280-91, 2014 (PubMed).

Hwang, Hsu, Yu, Liu, Yang: "Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice." in: PLoS ONE, Vol. 8, Issue 4, pp. e60730, 2013 (PubMed).

Carta, Frau, Pisanu, Wardas, Spiga, Carboni: "Rosiglitazone decreases peroxisome proliferator receptor-? levels in microglia and inhibits TNF-? production: new evidences on neuroprotection in a progressive Parkinson's disease model." in: Neuroscience, Vol. 194, pp. 250-61, 2011 (PubMed).

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