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ATM 抗体

ATM 适用: 人 WB 宿主: 小鼠 Monoclonal 4H1 unconjugated
产品编号 ABIN1449283
发货至: 中国
  • 抗原 See all ATM 抗体
    ATM (Ataxia Telangiectasia Mutated (ATM))
    适用
    • 154
    • 81
    • 34
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    宿主
    • 133
    • 21
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    小鼠
    克隆类型
    • 129
    • 33
    单克隆
    标记
    • 78
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    This ATM antibody is un-conjugated
    应用范围
    • 71
    • 46
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    • 8
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    • 1
    Western Blotting (WB)
    序列
    CP-CFIKKPFDRG EVESMEDDTN GN
    特异性
    This antibody reacts with ATM.
    交叉反应 (详细)
    Species reactivity (tested):Human
    免疫原
    Carrier protein (CP) conjugated synthetic peptide
    克隆位点
    4H1
    亚型
    IgG1
    Top Product
    Discover our top product ATM Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Protein A agarose, PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Upon receipt, store (in aliqouts) at -20 °C.
  • 抗原
    ATM (Ataxia Telangiectasia Mutated (ATM))
    别名
    ATM (ATM 产品)
    别名
    ATM antibody, Atm antibody, CG6535 antibody, Dmel\\CG6535 antibody, Tefu antibody, atm antibody, atm/tefu antibody, dATM antibody, tef antibody, Xatm antibody, at1 antibody, atdc antibody, tel1 antibody, telo1 antibody, AT1 antibody, ATA antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, TEL1 antibody, TELO1 antibody, AI256621 antibody, C030026E19Rik antibody, telomere fusion antibody, ATM serine/threonine kinase L homeolog antibody, ATM serine/threonine kinase antibody, ataxia telangiectasia mutated antibody, ataxia telangiectasia mutated (atm) antibody, serine/threonine-protein kinase ATM antibody, tefu antibody, atm.L antibody, atm antibody, ATM antibody, EDI_100660 antibody, CpipJ_CPIJ001772 antibody, BDBG_08252 antibody, PAAG_02532 antibody, MCYG_05088 antibody, VDBG_06833 antibody, ACLA_015700 antibody, LOC5565620 antibody, MGYG_07634 antibody, PGTG_14279 antibody, Atm antibody
    背景
    ATM (ataxia telangiectasia mutated) encodes a 350-370 kDa protein. The ATM protein belongs to a family of protein kinases that appear to be involved in cell cycle control and DNA damage response. ATM kinase activity is enhanced immediately after exposure of cells to DNA double strand breaks. The C-terminal region of the protein has extensive homology to the catalytic domain of PI-3 (phosphatydilinositol-3) kinase, FAT (FRAP/ATM/TRAPP), and FAT-C (FAT-carboxy-terminal). ATM activates p53, increasing p21Cip1 levels, thus blocking activation of cdk2. That results in blockage of the G1/S transition.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
    基因ID
    472
    NCBI登录号
    NP_000042
    UniProt
    Q13315
    途径
    p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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