×
我们推荐在您的浏览器上开启Javascript,以获得最佳效果。
ATM 抗体
ATM
适用: 人
WB
宿主: 小鼠
Monoclonal
4H1
unconjugated
ATM抗体详情
(hide)
抗原
See all ATM 抗体
ATM
(Ataxia Telangiectasia Mutated (ATM))
适用
All reactivities for ATM 抗体
人
宿主
All hosts for ATM 抗体
小鼠
克隆类型
All clonalities for ATM 抗体
单克隆
标记
All conjugates for ATM 抗体
This ATM antibody is un-conjugated
应用范围
All applications for ATM 抗体
Western Blotting (WB)
序列
CP-CFIKKPFDRG EVESMEDDTN GN
特异性
This antibody reacts with ATM.
交叉反应 (详细)
Species reactivity (tested):Human
免疫原
Carrier protein (CP) conjugated synthetic peptide
克隆位点
4H1
亚型
IgG1
Top Product
Discover our top product ATM Primary Antibody
Alternatives
(show)
使用细节
(hide)
应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
(hide)
浓度
1.0 mg/mL
缓冲液
Protein A agarose, PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
储存液
Without preservative
注意事项
Avoid repeated freezing and thawing.
储存条件
-20 °C
储存方法
Upon receipt, store (in aliqouts) at -20 °C.
ATM目标详情
(hide)
抗原
ATM
(Ataxia Telangiectasia Mutated (ATM))
别名
ATM (ATM 产品 )
别名
ATM antibody, Atm antibody, CG6535 antibody, Dmel\\CG6535 antibody, Tefu antibody, atm antibody, atm/tefu antibody, dATM antibody, tef antibody, Xatm antibody, at1 antibody, atdc antibody, tel1 antibody, telo1 antibody, AT1 antibody, ATA antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, TEL1 antibody, TELO1 antibody, AI256621 antibody, C030026E19Rik antibody, telomere fusion antibody, ATM serine/threonine kinase L homeolog antibody, ATM serine/threonine kinase antibody, ataxia telangiectasia mutated antibody, ataxia telangiectasia mutated (atm) antibody, serine/threonine-protein kinase ATM antibody, tefu antibody, atm.L antibody, atm antibody, ATM antibody, EDI_100660 antibody, CpipJ_CPIJ001772 antibody, BDBG_08252 antibody, PAAG_02532 antibody, MCYG_05088 antibody, VDBG_06833 antibody, ACLA_015700 antibody, LOC5565620 antibody, MGYG_07634 antibody, PGTG_14279 antibody, Atm antibody
背景
ATM (ataxia telangiectasia mutated) encodes a 350-370 kDa protein. The ATM protein belongs to a family of protein kinases that appear to be involved in cell cycle control and DNA damage response. ATM kinase activity is enhanced immediately after exposure of cells to DNA double strand breaks. The C-terminal region of the protein has extensive homology to the catalytic domain of PI-3 (phosphatydilinositol-3) kinase, FAT (FRAP/ATM/TRAPP), and FAT-C (FAT-carboxy-terminal). ATM activates p53, increasing p21Cip1 levels, thus blocking activation of cdk2. That results in blockage of the G1/S transition.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
基因ID
472
NCBI登录号
NP_000042
UniProt
Q13315
途径
p53 Pathway , Apoptosis , DNA Damage Repair , Inositol Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus
Recently viewed
(hide)