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TMPRSS6 抗体 (AA 711-811) (Cy5)

TMPRSS6 适用: 人 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal Cy5
产品编号 ABIN1416138
发货至: 中国
  • 抗原 See all TMPRSS6 抗体
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    抗原表位
    • 14
    • 8
    • 8
    • 6
    • 5
    • 2
    • 1
    AA 711-811
    适用
    • 45
    • 8
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    宿主
    • 43
    • 2
    克隆类型
    • 45
    多克隆
    标记
    • 13
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TMPRSS6 antibody is conjugated to Cy5
    应用范围
    • 39
    • 21
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Matriptase 2
    亚型
    IgG
    Top Product
    Discover our top product TMPRSS6 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    别名
    Matriptase 2 (TMPRSS6 产品)
    别名
    IRIDA antibody, 1300008A22Rik antibody, transmembrane protease, serine 6 antibody, transmembrane serine protease 6 antibody, Tmprss6 antibody, TMPRSS6 antibody
    背景

    Synonyms: Matriptase-2, Matriptase2, Membrane type serine proteinase 2, MTSP 2, MTSP2, PVAE354, TMPRSS 6, TMPRSS6, TMPS6_HUMAN, TMSP 6, TMSP6, Transmembrane protease serine 6, Type II Membrane Serine Proteinase 6.

    Background: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.Involvement in disease:Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA), also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.

    基因ID
    164656
    途径
    Transition Metal Ion Homeostasis
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