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KCTD11 抗体 (Alexa Fluor 555)

KCTD11 适用: 人, 小鼠, 大鼠 WB, IF (p) 宿主: 兔 Polyclonal Alexa Fluor 555
产品编号 ABIN1403795
发货至: 中国
  • 抗原 See all KCTD11 抗体
    KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
    适用
    • 21
    • 18
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 20
    • 1
    克隆类型
    • 21
    多克隆
    标记
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCTD11 antibody is conjugated to Alexa Fluor 555
    应用范围
    • 21
    • 12
    • 4
    • 2
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human KCTD11
    亚型
    IgG
    Top Product
    Discover our top product KCTD11 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
    别名
    KCTD11 (KCTD11 产品)
    别名
    KCTD11 antibody, AF465352 antibody, Ren antibody, C17orf36 antibody, KCASH1 antibody, REN antibody, REN/KCTD11 antibody, potassium channel tetramerization domain containing 11 antibody, potassium channel tetramerisation domain containing 11 antibody, KCTD11 antibody, Kctd11 antibody
    背景

    Synonyms: C17orf36, MGC 129844, Potassium channel tetramerisation domain containing 11, REN, Retinoic acid EGF NGF induced gene protein, C 17 orf 36, KCD11_HUMAN.

    Background: The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.

    基因ID
    147040
    途径
    Hedgehog Signaling
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