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RAPGEF3 抗体 (AA 301-400)

RAPGEF3 适用: 人, 大鼠 ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1387844
发货至: 中国
  • 抗原 See all RAPGEF3 抗体
    RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
    抗原表位
    • 14
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    适用
    • 55
    • 38
    • 32
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    人, 大鼠
    宿主
    • 53
    • 2
    克隆类型
    • 43
    • 12
    多克隆
    标记
    • 25
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAPGEF3 antibody is un-conjugated
    应用范围
    • 28
    • 16
    • 12
    • 12
    • 12
    • 10
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    人, 大鼠
    预测反应
    Mouse,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Epac1
    亚型
    IgG
    Top Product
    Discover our top product RAPGEF3 Primary Antibody
  • 应用备注
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
    别名
    Epac1 (RAPGEF3 产品)
    别名
    RAPGEF3 antibody, epac antibody, si:dkey-27m20.2 antibody, CAMP-GEFI antibody, EPAC antibody, EPAC1 antibody, HSU79275 antibody, bcm910 antibody, 2310016P22Rik antibody, 9330170P05Rik antibody, Epac antibody, Epac1 antibody, Rap guanine nucleotide exchange factor 3 antibody, Rap guanine nucleotide exchange factor 3 S homeolog antibody, Rap guanine nucleotide exchange factor (GEF) 3 antibody, RAPGEF3 antibody, rapgef3.S antibody, rapgef3 antibody, Rapgef3 antibody
    背景

    Synonyms: bcm910, CAMP GEFI, cAMP regulated guanine nucleotide exchange factor I, CAMPGEFI, CGEF 1, CGEF1, EPA1, Epac 1, EPAC, EPAC1, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, MGC21410, RAP guanine nucleotide exchange factor, Rap guanine nucleotide exchange factor GEF 3, RAP guanine nucleotide exchange factor 3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, RAPGEF3.

    Background: The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade. There are 2 members of the Epac family, Epac1 and Epac 2. Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, Egl-10 and pleckstrin homology domain) targeting the membrane anchors. EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity. EPAC1 mRNA is broadly expressed, with particularly high levels occurring in the thyroid, ovary, kidney and certain brain regions, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands. Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex. The Epac 1-selective were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains. The to Epac 1are affinity purified over immobilized antigen based chromatography.

    基因ID
    1019
    途径
    cAMP Metabolic Process
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