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APOE 抗体 (AA 151-250)

Name: APOE 抗体 (AA 151-250)
SKU: ABIN1386767
Availability: OutOfStock

APOE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Paraformaldehyde-fixed, paraffin embedded mouse brain, Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Apolipoprotein E Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining.

IHC (p)

Paraformaldehyde-fixed, paraffin embedded rat liver, Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Apolipoprotein E Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining.

IHC (p)

2 images

(1 reference)

产品编号 ABIN1386767

发货至: 中国

Datasheet as PDF

抗原 See all APOE 抗体

APOE (Apolipoprotein E (APOE))
抗原表位
15

15

14

5

5

5

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 151-250
适用
101

74

55

2

2

2

1

1
人, 小鼠, 大鼠
宿主
102

22

13

2
兔
Compatible Secondaries
克隆类型
104

34
多克隆
标记
59

18

12

7

4

4

4

4

4

4

3

3

3

3

3

2

2
This APOE antibody is un-conjugated
应用范围
110

56

38

38

30

24

20

11

10

9

7

5

3

2

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human APOE

亚型

IgG

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APOE 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 19-168) antibody
APOE 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated

anti-Apolipoprotein E (APOE) (C-Term) antibody
APOE 适用: 人 WB, ELISA, IP, IHC (p), ICC, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 200-300) antibody
APOE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) antibody
APOE 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1H4 unconjugated

anti-Apolipoprotein E (APOE) (N-Term) antibody
APOE 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 14-167) antibody
APOE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 16-175) antibody
APOE 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: "Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis." in: Molecular biology reports, Vol. 41, Issue 11, pp. 7507-23, (2014) (PubMed).
抗原

APOE (Apolipoprotein E (APOE))

别名

Apolipoprotein E (APOE 产品)

别名

ad2 antibody, apoprotein antibody, im:7036787 antibody, wu:fb69a05 antibody, zgc:110064 antibody, apoe antibody, AI255918 antibody, AD2 antibody, LDLCQ5 antibody, LPG antibody, APOEA antibody, Apo-E antibody, apolipoprotein E antibody, apolipoprotein Ea antibody, apoe antibody, apoea antibody, Apoe antibody, APOE antibody

背景

Synonyms: AD2, LPG, APO-E, LDLCQ5, Apolipoprotein E, APOE, ApoE3, APOE-epsilon3, ApoE4, APOE-epsilon4,
Background: Apolipoprotein-E (apoE) is a protein component of plasma lipoproteins that mediates the binding, internalization and catabolism of lipoprotein particles. It can serve as a ligand for several lipoprotein receptors, including the LDL (ApoB/E) receptor and the hepatic apoE (chylomicron remnant) receptor. apoE is produced in most organs and occurs in all plasma lipoprotein fractions, constituting 10-20 % of VLDL (very low density lipoprotein) and 1-2 % of HDL (high density lipoprotein). Three major isoforms of apoE have been described in human (E2, E3 and E4) which differ by only one or two amino acids. Estrogen receptor has been shown to upregulate apoE gene expression via the ERa-mediated pathway, indicating a potential role for apoE in atherosclerosis. This is consistent with studies in mice in which plasma apoE levels were raised, thereby protecting the mice from diet-induced atherosclerosis. apoE has also been shown to be a potent inhibitor of proliferation and thus may play a role in angiogenesis, tumor cell growth and metastasis.

基因ID

348

UniProt

P02649

途径

Regulation of Cell Size, Lipid Metabolism